Treximet: Difference between revisions
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| starting_dose = 1 tablet (85/500 mg sumatriptan/naproxen) PO at migraine onset; may repeat after 2 hours if needed; maximum 2 tablets per 24 hours | | starting_dose = 1 tablet (85/500 mg sumatriptan/naproxen) PO at migraine onset; may repeat after 2 hours if needed; maximum 2 tablets per 24 hours | ||
| preparations = 85 mg sumatriptan / 500 mg naproxen sodium tablets; lower-dose 10/60 mg pediatric (Treximet pediatric) | | preparations = 85 mg sumatriptan / 500 mg naproxen sodium tablets; lower-dose 10/60 mg pediatric (Treximet pediatric) | ||
| fda_max = 2 tablets per 24 hours; ≤4 days per month to avoid | | fda_max = 2 tablets per 24 hours; ≤4 days per month to avoid medicine-overuse headache | ||
| pill_id = | | pill_id = | ||
| routes = Oral | | routes = Oral | ||
Revision as of 04:53, 23 May 2026
Sumatriptan / Naproxen
Treximet
Experience
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Summary
Common uses
Acute migraine treatment (with or without aura)0
Pharmacy
Starting dose
1 tablet (85/500 mg sumatriptan/naproxen) PO at migraine onset; may repeat after 2 hours if needed; maximum 2 tablets per 24 hours
Preparations
85 mg sumatriptan / 500 mg naproxen sodium tablets; lower-dose 10/60 mg pediatric (Treximet pediatric)
US FDA Max
2 tablets per 24 hours; ≤4 days per month to avoid medicine-overuse headache
Pharmacology
Routes
Oral
Onset
Headache relief at 30-60 minutes
Duration
4-8 hours
Half-life
Sumatriptan ~2.5 hours; naproxen 12-15 hours[1]
Bioavailability
Sumatriptan ~15% (oral; substantial first-pass); naproxen ~95%[1]
Pregnancy
Avoid; NSAID-class restriction after 20 weeks (FDA 2020) and limited triptan pregnancy data.[citation needed]
Legal status
Purported mechanism
Sumatriptan is a selective 5-HT1B and 5-HT1D receptor agonist that vasoconstricts intracranial arteries and inhibits trigeminal nerve transmission, reversing the neurovascular mechanism of migraine. Naproxen is a non-selective NSAID providing anti-inflammatory adjuvant effect; the combination outperforms either agent alone in randomized trials (faster onset, longer-lasting relief, lower 24-hour recurrence).0 The dual-mechanism design exploits the inflammatory component of migraine that triptan monotherapy does not fully address. Risk of serotonin syndrome with SSRIs/SNRIs is theoretical but generally not seen clinically at triptan doses[1].
References
- ↑ 1.0 1.1 1.2 1.3 FDA Prescribing Information, Treximet (sumatriptan / naproxen sodium), Currax Pharmaceuticals, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021926s022lbl.pdf