Ibuprofen: Difference between revisions
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{{MedTemplate | {{MedTemplate | ||
| generic = Ibuprofen | | generic = Ibuprofen | ||
| brand | | brand = Advil, Motrin, IBU, Caldolor (IV), NeoProfen (neonatal IV) | ||
| classes = NSAID | | structure = | ||
| | | classes = [[:Category:NSAIDs|Non-steroidal anti-inflammatory (NSAID, non-selective)]], [[:Category:Analgesics|Analgesic]], [[:Category:Antipyretics|Antipyretic]] | ||
| uses = <vote slug="mild-moderate-pain-use">Mild-to-moderate pain (FDA)</vote>, <vote slug="fever-use">Fever (FDA, including pediatric)</vote>, <vote slug="dysmenorrhea-use">Primary dysmenorrhea (FDA)</vote>, <vote slug="osteoarthritis-use">Osteoarthritis (FDA)</vote>, <vote slug="rheumatoid-arthritis-use">Rheumatoid arthritis (FDA)</vote>, <vote slug="juvenile-ra-use">Juvenile rheumatoid arthritis (FDA)</vote>, <vote slug="pda-closure-use">Patent ductus arteriosus closure in preterm neonates (NeoProfen)</vote> | |||
| starting_dose = 200-400 mg PO every 4-6 hours as needed. OTC max 1200 mg/day without provider direction; prescription max 3200 mg/day divided | |||
| preparations = Tablets 200, 400, 600, 800 mg; capsules 200 mg; oral suspension 100 mg/5 mL; chewable tablets 100 mg; injection 100 mg/mL (Caldolor) | |||
| fda_max = 3200 mg/day (Rx); 1200 mg/day (OTC, without provider direction) | |||
| pill_id = | |||
| routes = Oral, intravenous (Caldolor, NeoProfen) | |||
| onset = 30-60 minutes (oral) | |||
| duration = 4-6 hours | |||
| halflife = 2-4 hours<ref name="motrin-label">FDA Prescribing Information, Motrin (ibuprofen), Pfizer/various, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/017463s105lbl.pdf</ref> | |||
| bioavailability = ~80-100% (oral)<ref name="motrin-label" /> | |||
| pregnancy = Avoid from 20 weeks gestation onward per FDA's 2020 expanded NSAID warning (fetal renal dysfunction, oligohydramnios); contraindicated from 30 weeks (risk of premature ductus arteriosus closure)<ref name="motrin-label" /> | |||
| legal = [[USLegal:Over-the-counter|OTC]] in the US at ≤200 mg per tablet / ≤1200 mg/day; [[USLegal:Prescription only|Rx-only]] at higher strengths and indications | |||
| mechanism = <vote slug="ibuprofen-mech-claim">Non-selective inhibitor of both COX-1 and COX-2 (cyclooxygenase) isoforms, reducing prostaglandin synthesis to produce analgesic, anti-inflammatory, and antipyretic effects. Like all NSAIDs, carries the FDA Boxed Warning for cardiovascular thrombotic events and gastrointestinal bleeding, with additional acute kidney injury risk particularly in volume-depleted or elderly patients.</vote> Clinical pearl: when taken before low-dose aspirin, ibuprofen reversibly occupies the COX-1 site and blocks aspirin's irreversible platelet acetylation, blunting cardioprotection. The FDA-suggested workaround is to take aspirin at least 30 minutes before ibuprofen, or ≥8 hours after<ref name="motrin-label" />. | |||
}} | }} | ||
== References == | |||
<references /> | |||
[[Category:NSAIDs]] | |||
[[Category:Analgesics]] | |||
[[Category:Antipyretics]] | |||