Phencyclidine: Difference between revisions

| legal            = [[USLegal:DEA Schedule II|Schedule II]] controlled substance in US (rescheduled from Schedule III in 1978). No accepted medical use. UN Convention on Psychotropic Substances Schedule II internationally.<ref name="dea-scheduling" />

| mechanism        = <vote slug="phencyclidine-mech-claim">Phencyclidine is a non-competitive open-channel blocker of the NMDA glutamate receptor, binding to a site within the channel pore (the "PCP site", named for this medicine) that is accessible only when the channel is open; the resulting use-dependent block produces dissociation, anesthesia, and the broad cognitive disruption characteristic of NMDA antagonism.</vote> Secondary activity at sigma-1 receptors (agonist), the dopamine transporter (weak inhibition), and nicotinic acetylcholine receptors (antagonist) shapes the distinctive clinical profile compared with the cleaner profile of ketamine.<ref name="anis-1983">Anis NA, Berry SC, Burton NR, Lodge D. The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate. ''British Journal of Pharmacology'' 1983;79(2):565-575.{{citation needed}}</ref> Metabolized by [[CYP3A4]] and [[CYP2B6]]; the parent compound is the principal active species.

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