Fluoxetine: Difference between revisions
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MDElliottMD (talk | contribs) Proposed effect: Persistent Sexual Dysfunction |
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| mechanism = [https://pmc.ncbi.nlm.nih.gov/articles/PMC9666396/ TrkB/BDNF] <vote slug="ssri-claim">Fluoxetine is a selective serotonin reuptake inhibitor.</vote> | | mechanism = [https://pmc.ncbi.nlm.nih.gov/articles/PMC9666396/ TrkB/BDNF] <vote slug="ssri-claim">Fluoxetine is a selective serotonin reuptake inhibitor.</vote> | ||
| intro = Fluoxetine was the first of a long line of SSRIs. It is notable for its extremely long half-life and relative lack of withdrawal syndrome. It can also be useful in helping taper and discontinue other SxRI medicines. | | intro = Fluoxetine was the first of a long line of SSRIs. It is notable for its extremely long half-life and relative lack of withdrawal syndrome. It can also be useful in helping taper and discontinue other SxRI medicines. | ||
| | | pk_absorption = | ||
| pk_distribution = | |||
| pk_metabolism = | |||
| pk_elimination = | |||
| pharmacodynamics = | | pharmacodynamics = | ||
| indications = Anxiety disorders broadly (including panic, social anxiety, OCD), depressive disorders, potentially PTSD | | indications = Anxiety disorders broadly (including panic, social anxiety, OCD), depressive disorders, potentially PTSD | ||
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Start at 10 mg daily; increase by 10–20 mg every 2–6 weeks, up to 80 mg. OCD typically requires elevated doses (60–80 mg). | Start at 10 mg daily; increase by 10–20 mg every 2–6 weeks, up to 80 mg. OCD typically requires elevated doses (60–80 mg). | ||
</titration> | </titration> | ||
| effects = <effect ref="anxiolysis">Classically starting at 3–4 weeks and improving for another 8–12.</effect> | | effects = <effect ref="anxiolysis" author="MDElliottMD">Classically starting at 3–4 weeks and improving for another 8–12.</effect> | ||
<effect ref="delayed-ejaculation"/> | <effect ref="delayed-ejaculation" author="MDElliottMD"/> | ||
<effect ref="mood-enhancement"/> | <effect ref="mood-enhancement" author="MDElliottMD"/> | ||
<effect ref="nausea">Common, often improves over 1–2 weeks.</effect> | <effect ref="nausea" author="MDElliottMD">Common, often improves over 1–2 weeks.</effect> | ||
<effect ref="decreased-libido" author="MDElliottMD"/> | <effect ref="decreased-libido" author="MDElliottMD"/> | ||
<effect ref="temporary-erectile-dysfunction" author="MDElliottMD"/> | <effect ref="temporary-erectile-dysfunction" author="MDElliottMD"/> | ||
<effect ref="persistent-sexual-dysfunction" author="MDElliottMD"> | <effect ref="persistent-sexual-dysfunction" author="MDElliottMD"> | ||
Persistent sexual dysfunction, historically [https://pmc.ncbi.nlm.nih.gov/articles/PMC11450419/ associated with SSRIs] | Persistent sexual dysfunction, historically [https://pmc.ncbi.nlm.nih.gov/articles/PMC11450419/ associated with SSRIs] | ||
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Fluoxetine is great for getting off other SxRIs! Especially venlafaxine and duloxetine. | Fluoxetine is great for getting off other SxRIs! Especially venlafaxine and duloxetine. | ||
</anecdote> | </anecdote> | ||
| seealso = [[Sertraline]], [[Duloxetine]] | | seealso = [[Sertraline]], [[Duloxetine]] | ||
| references = | | references = | ||
}} | }} | ||