Halothane
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Inhalational anesthetic
Halothane
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Interactions
Pharmacogenomic + mechanism interactions
Pharmacogenomic guideline recommendationsCPIC and Dutch Pharmacogenetics Working Group clinical guidelines
CPIC rec 8093917 [Strong]: Halogenated volatile anesthetics or the depolarizing muscle relaxant succinylcholine are relatively contraindicated in persons with malignant hyperthermia susceptibility (MHS). They should not be used, except in extraordinary circumstances where the benefits outweigh the risks. In general, alternative anesthetics are widely available and effective in patients with MHS. CPIC pair-level A (RYR1, CACNA1S and Volatile anesthetic agents and Succinylcholine) [PMID 30499100]
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CPIC rec 8093917 [Strong]: Halogenated volatile anesthetics or the depolarizing muscle relaxant succinylcholine are relatively contraindicated in persons with malignant hyperthermia susceptibility (MHS). They should not be used, except in extraordinary circumstances where the benefits outweigh the risks. In general, alternative anesthetics are widely available and effective in patients with MHS. CPIC pair-level A (RYR1, CACNA1S and Volatile anesthetic agents and Succinylcholine) [PMID 30499100]
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CPIC rec 8093918 [Strong]: Halogenated volatile anesthetics or the depolarizing muscle relaxant succinylcholine are relatively contraindicated in persons with malignant hyperthermia susceptibility (MHS). They should not be used, except in extraordinary circumstances where the benefits outweigh the risks. In general, alternative anesthetics are widely available and effective in patients with MHS. CPIC pair-level A (RYR1, CACNA1S and Volatile anesthetic agents and Succinylcholine) [PMID 30499100]
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CPIC rec 8093918 [Strong]: Halogenated volatile anesthetics or the depolarizing muscle relaxant succinylcholine are relatively contraindicated in persons with malignant hyperthermia susceptibility (MHS). They should not be used, except in extraordinary circumstances where the benefits outweigh the risks. In general, alternative anesthetics are widely available and effective in patients with MHS. CPIC pair-level A (RYR1, CACNA1S and Volatile anesthetic agents and Succinylcholine) [PMID 30499100]
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CPIC rec 8093923 [Strong]: No CACNA1S genotype is available. Based on RYR1 status, clinical findings, family history, further genetic testing and other laboratory data should guide use of halogenated volatile anesthetics or depolarizing muscle relaxants. CPIC pair-level A (RYR1, CACNA1S and Volatile anesthetic agents and Succinylcholine) [PMID 30499100]
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CPIC rec 8093924 [Strong]: No RYR1 genotype is available. Based on CACNA1S status, clinical findings, family history, further genetic testing and other laboratory data should guide use of halogenated volatile anesthetics or depolarizing muscle relaxants. CPIC pair-level A (RYR1, CACNA1S and Volatile anesthetic agents and Succinylcholine) [PMID 30499100]
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Summary
Classes
Inhalational anesthetic
Common uses
Pharmacy
Pharmacology
Purported mechanism
GABAA potentiator; NMDA antagonist