Quetiapine
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Antipsychotic, Neuroleptic
Quetiapine
Seroquel
Experience
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Effects
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Interactions
Pharmacogenomic + mechanism interactions
Pharmacogenomic guideline recommendationsCPIC and Dutch Pharmacogenetics Working Group clinical guidelines
DPWG guideline: Patients who are CYP3A4 poor metabolizers and being treated for depression should be given an alternative drug. Patients being treated for other indications and who are CYP3A4 poor metabolizers should be given a reduced dose of quetiapine. No action is needed for patients who are CYP3A4 intermediate metabolizers. ClinPGx uses CYP3A4 allele nomenclature as defined by PharmVar , while the current version of this guideline issued by the DPWG uses retired allele names. Further details are given on the DPWG curation page .
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Clinical relevance: does this interaction matter in practice?trivialcritical
Mechanism description, if it needs work:
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Experience (1 a little, 5 a lot)
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DPWG guideline: Patients who are CYP3A4 poor metabolizers and being treated for depression should be given an alternative drug. Patients being treated for other indications and who are CYP3A4 poor metabolizers should be given a reduced dose of quetiapine. No action is needed for patients who are CYP3A4 intermediate metabolizers. ClinPGx uses CYP3A4 allele nomenclature as defined by PharmVar , while the current version of this guideline issued by the DPWG uses retired allele names. Further details are given on the DPWG curation page .
Rate this interaction. Reports are anonymous and help curate the page.
Clinical relevance: does this interaction matter in practice?trivialcritical
Mechanism description, if it needs work:
Is this row worth surfacing?
Your own experience with this combination:
Experience (1 a little, 5 a lot)
Outcome (-100 worst, +100 best)
Patient experience
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Summary
Classes
Antipsychotic, Neuroleptic
Pharmacy
Pharmacology
Purported mechanism
D2/5-HT2A antagonist; strong H1 antagonist