Caffeine
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Xanthine, Stimulant
Caffeine
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Interactions
Pharmacogenomic + mechanism interactions
Pharmacokinetic mechanismSubstrate / metabolism relationships from primary literature
FDA Drug Interactions Table: sensitive index substrate of CYP1A2.
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Clinical relevance: does this interaction matter in practice?trivialcritical
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Inferred from pharmacokinetic dataMaterialised by the inference engine; provenance shown per row
Fluvoxamine inhibits CYP1A2 (inhibitor_strong, intensity 90); Caffeine is a substrate_major of CYP1A2 (intensity 80). Derived: Caffeine exposure raised.
Inferred via Enzyme:CYP1A2 (exposure raised)
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Clinical relevance: does this interaction matter in practice?trivialcritical
Confidence in this inference: is the inferred magnitude sound?overstatedsound
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Summary
Classes
Xanthine, Stimulant
Common uses
Pharmacy
Pharmacology
Purported mechanism
Adenosine receptor antagonist
“Pendell's corner
1,3,7-trimethylxanthine — the alkaloid the coffee leaf shares with the tea leaf and the cocoa pod and the kola nut and the maté and the guaraná. The world's most-consumed psychoactive molecule, the one we forget is psychoactive because we have built our days around it. Caffeine is the conversation that civilization has stopped noticing it is having.
— Dale Pendell, Pharmako/Dynamis
curated paraphrase — replace with verbatim passage
curated paraphrase — replace with verbatim passage