Psilocybin

Classic Psychedelic, Tryptamine

Psilocybin

Experience

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Problems

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Titration strategies

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Effects

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Summary

Classes

Classic Psychedelic, Tryptamine

Common uses

• Alcohol Use Disorder★★★★★★★★★★★★★★★—×
• Cancer-Related Distress★★★★★★★★★★★★★★★—×
• Cluster headache★★★★★★★★★★★★★★★—×
• Major Depressive Disorder★★★★★★★★★★★★★★★—×
• Obsessive-Compulsive Disorder★★★★★★★★★★★★★★★—×

+ 2 more uses →

Pharmacy

Pharmacology

Purported mechanism

Prodrug of psilocin; 5-HT2A agonist

“Pendell's corner

María Sabina sang the mushrooms in Mazatec. Wasson published her in Life magazine. By the time the molecule was named, the song had escaped the village. Psilocybin is the most generous of the Allies — gentle in dose, generous in vision, willing to meet the unprepared more than half-way. She does not demand the surrender that her sister Salvia demands, but she rewards it just as fully.

— Dale Pendell, Pharmako/Gnosis
curated paraphrase — replace with verbatim passage