Ketamine

ketamine

ketalar

Experience

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Problems

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Titration strategies

Insufflated dose ladder (Erowid)▲0▼×

Erowid's dosage documentation for insufflated ketamine reports the following tiers:

• Threshold: 10-15 mg
• Light: 15-30 mg
• Common: 30-75 mg
• Strong: 60-125 mg
• K-hole: 100-250 mg

Onset 5 to 15 minutes; duration 45 to 60 minutes with aftereffects 1 to 3 hours. The "K-hole" -- a state of profound dissociation and anesthesia-adjacent experience -- is a recognized category in ketamine harm-reduction literature, distinct from the "strong" tier in

character as well as magnitude.

Oral dose ladder (Erowid)▲0▼×

Oral tiers reported by Erowid:

• Threshold: 40-50 mg
• Light: 50-100 mg
• Common: 75-300 mg
• Strong: 200-450 mg
• K-hole: 500+ mg

Onset 5 to 20 minutes depending on stomach contents; duration approximately 90 minutes with aftereffects 4 to 8 hours. Oral doses

are substantially higher than insufflated for equivalent effect.

Intramuscular dose ladder (Erowid)▲0▼×

IM tiers reported by Erowid:

• Threshold: 10-15 mg
• Light: 15-30 mg
• Common: 25-50 mg
• Strong: 40-100 mg
• K-hole: 60-125 mg
• Anesthetic: 100-200 mg

Onset 1 to 5 minutes; duration 30 to 60 minutes with aftereffects 2 to 4 hours. Erowid also notes IV anesthetic dosing at 1-4.5 mg/kg

body weight.

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Effects

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Interactions

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Relevant Literature

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Summary

Common uses

Pharmacy

Pharmacology

Purported mechanism

NMDA-receptor antagonism