Ayahuasca

Classic Psychedelic, Botanical

Ayahuasca

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Summary

Classes

Classic Psychedelic, Botanical

Common uses

Pharmacy

Pharmacology

Purported mechanism

DMT + MAOI (harmine/harmaline); 5-HT2A agonist

“Pendell's corner

Two plants make one brew, and the brew is the teacher. The vine without the leaf is asleep; the leaf without the vine is mute. Banisteriopsis is the rope that climbs out of the underworld and Psychotria is the voice that comes down to meet you on the rope. The shaman is the third necessity — the human throat through which the medicine remembers it once belonged to people.

— Dale Pendell, Pharmako/Gnosis
curated paraphrase — replace with verbatim passage