Venlafaxine
SNRI, Antidepressant
Venlafaxine
Effexor
Experience
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Effects
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Interactions
Pharmacogenomic + mechanism interactions
Pharmacogenomic guideline recommendationsCPIC and Dutch Pharmacogenetics Working Group clinical guidelines
CPIC rec 8095268 [Strong]: Initiate therapy with recommended starting dose. CPIC pair-level B (CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants) [PMID 37032427]
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Clinical relevance: does this interaction matter in practice?trivialcritical
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CPIC rec 8095277 [Optional]: Consider a clinically appropriate alternative antidepressant not predominantly metabolized by CYP2D6. CPIC pair-level B (CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants) [PMID 37032427] FDA labeling (Drug Interactions, Use in Specific Populations, Clinical Pharmacology)
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Clinical relevance: does this interaction matter in practice?trivialcritical
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CPIC rec 8095261 [No Recommendation]: No action recommended based on genotype for venlafaxine because of minimal evidence regarding the impact on efficacy or side effects. CPIC pair-level B (CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants) [PMID 37032427]
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Clinical relevance: does this interaction matter in practice?trivialcritical
Mechanism description, if it needs work:
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Your own experience with this combination:
Experience (1 a little, 5 a lot)
Outcome (-100 worst, +100 best)
CPIC rec 8095273 [No Recommendation]: No action recommended based on genotype for venlafaxine because of minimal evidence regarding the impact on efficacy or side effects. CPIC pair-level B (CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants) [PMID 37032427]
Rate this interaction. Reports are anonymous and help curate the page.
Clinical relevance: does this interaction matter in practice?trivialcritical
Mechanism description, if it needs work:
Is this row worth surfacing?
Your own experience with this combination:
Experience (1 a little, 5 a lot)
Outcome (-100 worst, +100 best)
Patient experience
Fluoxetine via Category:Antidepressants exp n/a/5 outcome n/a (n=1) exp 1.0/5 outcome +33.0 (n=1)
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- checking this mechanism here
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Summary
Classes
SNRI, Antidepressant
Common uses
Pharmacy
Pharmacology
Purported mechanism
Serotonin–norepinephrine reuptake inhibitor