Benazepril
Benazepril
Lotensin
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Summary
Classes
Common uses
Hypertension0, Heart failure0, Diabetic nephropathy0
Pharmacy
Starting dose
10 mg PO once daily (5 mg if on a diuretic); titrate to 40 mg
Preparations
5, 10, 20, 40 mg tablets
US FDA Max
80 mg/d
Pharmacology
Routes
Oral
Onset
BP lowering within 1 hour; max at 6 hours
Duration
24 hours
Half-life
10-11 hours (benazeprilat, the active metabolite)[1]
Bioavailability
~37% (oral; food does not affect)[1]
Pregnancy
Contraindicated in pregnancy (all trimesters); fetal renal injury, oligohydramnios, skull hypoplasia, hypotension. Stop on detection[1]
Legal status
Rx-only in US
Purported mechanism
Benazepril is a prodrug hydrolyzed to benazeprilat, a long-acting ACE inhibitor that blocks conversion of angiotensin I to angiotensin II, reducing vasoconstriction, aldosterone secretion, and renal sodium retention.0 Like other ACE inhibitors, it raises bradykinin (driving the dry cough and rare angioedema). Renally cleared; dose-adjust in renal impairment[1].
References
- ↑ 1.0 1.1 1.2 1.3 FDA Prescribing Information, Lotensin (benazepril HCl), Novartis, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/019851s053lbl.pdf