Receptor:5-HT1A

5-HT1A is a G protein-coupled serotonin receptor and the most extensively studied member of the 5-HT1 receptor family, which couples to inhibitory Gi/o proteins and suppresses adenylyl cyclase activity. It is expressed both as a somatodendritic autoreceptor on raphe serotonergic neurons, where it regulates serotonergic tone, and as a postsynaptic receptor in the hippocampus, cortex, and limbic regions. 5-HT1A is the principal target of the anxiolytic buspirone and contributes to the action of several antidepressants; partial agonism at 5-HT1A is part of the receptor profile of the serotonergic psychedelics.

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