Eptinezumab
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Anti-CGRP ligand monoclonal antibody
Eptinezumab
Vyepti
Eptinezumab (brand name Vyepti) is the only IV-administered anti-CGRP monoclonal antibody, FDA-approved in 2020 for migraine prevention. The IV route gives faster onset than the subcutaneous CGRP mAbs.
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Summary
Classes
Anti-CGRP ligand monoclonal antibody
Common uses
Preventive treatment of migraine in adults
Pharmacy
Starting dose
100 mg IV every 3 months; may increase to 300 mg IV every 3 months
Preparations
100 mg/mL vial for IV infusion
US FDA Max
300 mg/quarter
Pharmacology
Routes
Intravenous infusion
Onset
Effect demonstrated within 24 hours in some patients
Duration
3-month dosing interval
Half-life
~27 days
Bioavailability
100% (IV)
Pregnancy
Limited data; avoid
Legal status
Rx
Purported mechanism
Humanized IgG1 monoclonal antibody binding CGRP peptide; IV infusion enables fastest onset of any CGRP mAb