Erenumab
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Anti-CGRP receptor monoclonal antibody
Erenumab
Aimovig
Erenumab (brand name Aimovig) was the first CGRP-pathway monoclonal antibody approved (FDA May 2018) for migraine prevention. Uniquely among the class, it targets the CGRP receptor rather than the CGRP peptide itself.
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Summary
Classes
Anti-CGRP receptor monoclonal antibody
Common uses
Preventive treatment of migraine in adults (episodic and chronic)
Pharmacy
Starting dose
70 mg SC monthly; may increase to 140 mg monthly
Preparations
70 mg/mL or 140 mg/mL prefilled autoinjector
US FDA Max
140 mg/month
Pharmacology
Routes
Subcutaneous
Onset
Onset of preventive effect over weeks; some patients respond after first dose
Duration
Monthly dosing
Half-life
~28 days
Bioavailability
~82% SC
Pregnancy
Limited data; avoid
Legal status
Rx
Purported mechanism
Humanized IgG2 monoclonal antibody binding the CGRP receptor (not the peptide); blocks CGRP-mediated vasodilation and nociceptive signaling