THCV

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Cannabinoid (minor), phytocannabinoid

Tetrahydrocannabivarin

Tetrahydrocannabivarin (THCV, delta-9-tetrahydrocannabivarin) is a minor phytocannabinoid found in some cannabis chemovars, most prominently in certain African landraces. It is the propyl-side-chain analogue of THC (a pentyl side chain in THC, a propyl side chain in THCV). At low doses THCV behaves as a neutral CB1 antagonist, opposing several effects of THC; at higher doses it becomes a partial CB1 agonist. This biphasic profile is why THCV is often described both as "the appetite-suppressing cannabinoid" (at low doses, opposing the appetite-stimulating CB1 agonism of THC) and as "diet weed" in marketing contexts. Clinical interest in THCV has focused on type 2 diabetes and obesity, with several small trials reporting modest favourable effects on glycaemic control and pancreatic beta-cell function; the evidence is preliminary and no THCV-containing product is approved for any indication.

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Summary

Classes

Cannabinoid (minor), phytocannabinoid

Common uses

Pharmacy

Pharmacology

Purported mechanism

Biphasic activity at CB1: neutral antagonist at low doses, partial agonist at high doses; partial agonist at CB2.