Tamsulosin
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Tamsulosin
Flomax
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Summary
Common uses
Benign prostatic hyperplasia (LUTS)0, Medical expulsive therapy for distal ureteral stones0
Pharmacy
Starting dose
0.4 mg PO once daily, 30 minutes after the same meal each day
Preparations
0.4 mg capsules
US FDA Max
0.8 mg/d (rarely needed)
Pharmacology
Routes
Oral
Onset
Symptom improvement within 1 week; peak effect at 4-6 weeks
Duration
24 hours
Half-life
9-15 hours[1]
Bioavailability
>90% (oral; food slows absorption and reduces peaks, hence the post-meal dosing rule)[1]
Pregnancy
Not applicable (male indication); historical Category B if used in unrelated female cases.[citation needed]
Legal status
Rx-only in US
Purported mechanism
Tamsulosin selectively antagonizes α1A adrenergic receptors, the dominant subtype in prostatic and bladder-neck smooth muscle, relaxing outflow tract tone and improving urodynamic flow with less peripheral hypotension than non-selective α-blockers.0 CYP3A4 and CYP2D6 substrate. The α1A-selective binding underlies intraoperative floppy iris syndrome (IFIS), a recognized cataract-surgery complication that does not reverse after stopping the drug; preoperative disclosure is standard[1].
References
edit- ↑ 1.0 1.1 1.2 FDA Prescribing Information, Flomax (tamsulosin HCl), Boehringer Ingelheim, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020579s044lbl.pdf