User contributions for MDElliottMD

19 May 2026

• 22:3922:39, 19 May 2026 diff hist +17,604 N Enzyme:CYP1A2 Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...
• 22:1122:11, 19 May 2026 diff hist +15,224 N User:MDElliottMD/Sandbox/CYP2B6 Sandbox-save CYP2B6 enzyme entity page (9th pharmacogenomics enzyme page). History-first spine: the rehabilitation of a long-neglected enzyme - Lang/Klein/Zanger Dr. Margarete Fischer-Bosch Institute Stuttgart 2001 polymorphism survey PMID 11470993. 16-row collapsible-sortable substrate table (efavirenz canonical, bupropion probe, methadone, cyclophosphamide/ifosfamide bioactivation, ketamine, others). Full PM/IM/NM/RM/UM phenotype classification per CPIC efavirenz guideline. Major variant *6...
• 22:0322:03, 19 May 2026 diff hist +17,604 N User:MDElliottMD/Sandbox/CYP1A2 Sandbox-save CYP1A2 enzyme entity page (8th pharmacogenomics enzyme page). History-first spine: Anthony Conney enzyme-induction research (Hoffmann-La Roche, Nutley NJ), 1982 Clowes Memorial Lecture PMID 6814745, AhR induction mechanism. 28-row collapsible-sortable substrate table (clozapine/olanzapine/theophylline/tizanidine headline substrates; caffeine probe; antidepressants, triptans, others). Phenotype section: honest no-PM/IM/NM-bedside-classification (like CYP3A4); variability dominated...
• 21:4421:44, 19 May 2026 diff hist +14,721 N User:MDElliottMD/Sandbox/NUDT15 Sandbox-save NUDT15 enzyme entity page (7th pharmacogenomics enzyme page, parallel to TPMT). History-first spine: Asan Medical Center Seoul 2014 GWAS in Korean IBD cohort discovering NUDT15 rs116855232 Arg139Cys, Yang 2014 Nat Genet PMID 25108385; Moriyama 2016 Nat Genet mechanism (St. Jude) PMID 26878724; Yang 2015 JCO ALL extension PMID 25624441; Moriyama 2017 Blood diverse-ancestry alleles PMID 28659275; Relling 2019 CPIC TPMT+NUDT15 PMID 30447069; PharmGKB Whirl-Carrillo 2021 PMID 3421602...
• 21:3521:35, 19 May 2026 diff hist +17,459 N User:MDElliottMD/Sandbox/TPMT Sandbox-save TPMT enzyme entity page (6th pharmacogenomics enzyme page). History-first spine: Weinshilboum & Sladek 1980 Mayo Clinic bimodal-distribution discovery PMID 7191632, one of the foundational pharmacogenetics demonstrations. Lennard 1989 azathioprine-toxicity link PMID 2758725; Krynetski 1995 PNAS TPMT*2 molecular variant PMID 7862671; Loennechen 1998 TPMT*3C PMID 9695718; Relling 2019 CPIC TPMT+NUDT15 thiopurine dosing PMID 30447069. NUDT15 cross-reference section cites Yang 2014 N...
• 21:0921:09, 19 May 2026 diff hist +19,985 N User:MDElliottMD/Sandbox/UGT1A1 Sandbox-save UGT1A1 enzyme entity page (5th of 10 pharmacogenomics enzyme pages). History-first spine: Gilbert 1901 Paris + Bosma 1995 NEJM Amsterdam closure (UGT1A1*28 promoter TA-repeat discovery). Two CPIC/DPWG guidelines cited: Gammal 2016 CPIC atazanavir PMID 26417955, Hulshof 2023 DPWG irinotecan PMID 36443464. Plus mechanistic refs Iyer 1998 JCI PMID 9466980 (UGT1A1 + SN-38), Innocenti 2004 JCO PMID 15007088 (irinotecan + UGT1A1*28 + neutropenia). Plus Tukey & Strassburg 2000 Annu Rev...
• 20:4420:44, 19 May 2026 diff hist +17,387 N User:MDElliottMD/Sandbox/CYP2C19 Retrofit CYP2C19 sandbox per Mark 2026-05-19 Option C decision: collapsible-sortable near-complete substrate table (32 rows: PPIs, SSRIs, clopidogrel/proguanil activation, voriconazole, diazepam, mephenytoin probe, carisoprodol, others; tier-tagged major/moderate/minor/partial; activation reactions flagged for clopidogrel and proguanil). Plus Comprehensive substrate and interaction tables pointer section. NOTE: also restored three CPIC-guideline ref definitions (cpic-clopidogrel-2022 PMID 350...
• 20:4420:44, 19 May 2026 diff hist +21,717 N User:MDElliottMD/Sandbox/CYP3A4 Retrofit CYP3A4 sandbox per Mark 2026-05-19 Option C decision: collapsible-sortable near-complete substrate table (57 rows: benzodiazepines, calcium channel blockers, statins, immunosuppressants, anti-cancer, macrolides, HIV protease inhibitors, DOACs, opioids, antifungals, PDE5 inhibitors, antihistamines, endogenous steroids, others; tier-tagged major/moderate/minor/partial). Plus Comprehensive substrate and interaction tables pointer section naming Flockhart Indiana University, FDA Drug Dev...
• 20:4420:44, 19 May 2026 diff hist +17,867 N User:MDElliottMD/Sandbox/CYP2D6 Retrofit CYP2D6 sandbox per Mark 2026-05-19 Option C decision: collapsible-sortable near-complete substrate table (49 rows: opioid prodrugs, TCAs, SSRIs/SNRIs, antipsychotics, beta blockers, antiarrhythmics, antiemetics, tamoxifen, atomoxetine, perhexiline, antihistamines, others; tier-tagged major/moderate/minor/partial; activation reactions flagged for codeine/tramadol/risperidone/tamoxifen/venlafaxine). Plus Comprehensive substrate and interaction tables pointer section naming Flockhart In...
• 20:1320:13, 19 May 2026 diff hist +14 User:MDElliottMD/Sandbox/CYP2C9 Expand CYP2C9 substrate section per Mark 2026-05-19 Option C decision: replace bullet list with 36-row sortable wikitable (substrate / therapeutic class / CYP2C9 contribution tier / clinical notes) covering anticoagulants, antiepileptics, NSAIDs, sulfonylureas, ARBs, statins, cannabinoids, antifungals, others. Add Comprehensive-tables pointer section naming Flockhart Indiana University table, FDA Drug Development table, PharmGKB (cited Whirl-Carrillo 2021 PMID 34216021). Add Zanger and Schwab...
• 20:0820:08, 19 May 2026 diff hist +67 User:MDElliottMD/Sandbox/CYP2C9 Expand CYP2C9 substrate section per Mark 2026-05-19 Option C decision: replace bullet list with 36-row sortable wikitable (substrate / therapeutic class / CYP2C9 contribution tier / clinical notes) covering anticoagulants, antiepileptics, NSAIDs, sulfonylureas, ARBs, statins, cannabinoids, antifungals, others. Add Comprehensive-tables pointer section naming Flockhart Indiana University table, FDA Drug Development table, PharmGKB (cited Whirl-Carrillo 2021 PMID 34216021). Add Zanger and Schwab...
• 20:0120:01, 19 May 2026 diff hist +123 User:MDElliottMD/Sandbox/CYP2C9 Expand CYP2C9 substrate section per Mark 2026-05-19 Option C decision: replace bullet list with 36-row sortable wikitable (substrate / therapeutic class / CYP2C9 contribution tier / clinical notes) covering anticoagulants, antiepileptics, NSAIDs, sulfonylureas, ARBs, statins, cannabinoids, antifungals, others. Add Comprehensive-tables pointer section naming Flockhart Indiana University table, FDA Drug Development table, PharmGKB (cited Whirl-Carrillo 2021 PMID 34216021). Add Zanger and Schwab...
• 19:5019:50, 19 May 2026 diff hist +7,014 User:MDElliottMD/Sandbox/CYP2C9 Expand CYP2C9 substrate section per Mark 2026-05-19 Option C decision: replace bullet list with 36-row sortable wikitable (substrate / therapeutic class / CYP2C9 contribution tier / clinical notes) covering anticoagulants, antiepileptics, NSAIDs, sulfonylureas, ARBs, statins, cannabinoids, antifungals, others. Add Comprehensive-tables pointer section naming Flockhart Indiana University table, FDA Drug Development table, PharmGKB (cited Whirl-Carrillo 2021 PMID 34216021). Add Zanger and Schwab...
• 19:3119:31, 19 May 2026 diff hist +13,862 N User:MDElliottMD/Sandbox/CYP2C9 Sandbox-save CYP2C9 enzyme entity page (4th of 10 pharmacogenomics enzyme pages). History-first spine: Rettie 1992 Seattle / S-warfarin / CYP2C9. Three CPIC guidelines cited: warfarin 2017 PMID 28198005, phenytoin 2020 PMID 32779747, NSAIDs 2020 PMID 32189324. Plus Rettie 1992 PMID 1581537, Sullivan-Klose 1996 PMID 8873220 (CYP2C9*3 / tolbutamide), Aithal 1999 PMID 10073515 (Lancet warfarin dose / bleeding). All 6 PMIDs NCBI-eutils-verified. Final home Enzyme:CYP2C9 once namespace registered.
• 19:2219:22, 19 May 2026 diff hist +28 Category:Κ-Opioid Receptor Agonists Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
• 19:2219:22, 19 May 2026 diff hist +28 Category:Z-Drugs (Non-Benzodiazepine Hypnotics) Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +47 Category:Xanthines Phase 2 retag: add Pharmaceutical + Plant root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +47 Category:Tryptamines Phase 2 retag: add Pharmaceutical + Plant root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +28 Category:Triptans (5-HT1B/1D Agonists) Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +28 Category:Tricyclic Antidepressants (TCAs) Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +28 Category:Third-Generation Antipsychotics Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +28 Category:Thioxanthenes Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +28 Category:Thienodiazepines Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +28 Category:Synthetic opioids Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
• 19:2219:22, 19 May 2026 diff hist +28 Category:Synthetic Cannabinoids Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
• 19:2219:22, 19 May 2026 diff hist +28 Category:Sodium channel blockers Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +28 Category:Serotonin–Norepinephrine Reuptake Inhibitors (SNRIs) Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
• 19:2219:22, 19 May 2026 diff hist +28 Category:Serotonin Antagonist and Reuptake Inhibitors (SARIs) Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
• 19:2219:22, 19 May 2026 diff hist +28 Category:Semisynthetic opioids Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
• 19:2219:22, 19 May 2026 diff hist +28 Category:Selective Serotonin Reuptake Inhibitors (SSRIs) Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
• 19:2219:22, 19 May 2026 diff hist +28 Category:Selective MAO-B inhibitors Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
• 19:2219:22, 19 May 2026 diff hist +28 Category:Sedative-Hypnotics Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +28 Category:Second-generation antihistamines Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
• 19:2219:22, 19 May 2026 diff hist +28 Category:Second-Generation Antipsychotics (SGAs / Atypicals) Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +28 Category:SV2A ligands Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +19 Category:Rhapsodica Phase 2 retag: add Plant root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +28 Category:Reversible MAO-A inhibitors (RIMAs) Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
• 19:2219:22, 19 May 2026 diff hist +28 Category:Research Materials Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +28 Category:Racetams Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +28 Category:Pyrrolidinophenones Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +47 Category:Psychostimulants Phase 2 retag: add Pharmaceutical + Plant root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +47 Category:Psychedelics Phase 2 retag: add Pharmaceutical + Plant root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +19 Category:Plant Medicines Phase 2 retag: add Plant root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +19 Category:Phytocannabinoids Phase 2 retag: add Plant root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +28 Category:Phenothiazines Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +47 Category:Phenethylamines Phase 2 retag: add Pharmaceutical + Plant root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +28 Category:Pharmaceutical Cannabinoids Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current
• 19:2219:22, 19 May 2026 diff hist +47 Category:Phantastica Phase 2 retag: add Pharmaceutical + Plant root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +28 Category:Peptide Nootropics Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20)
• 19:2219:22, 19 May 2026 diff hist +28 Category:Partial Mu-Opioid Agonists Phase 2 retag: add Pharmaceutical root parent (taxonomy restructure 2026-05-20) current