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18:55, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP3A4 poor metabolizer (Sandbox-save CYP3A4 phenotype page per parser-claude 2026-05-20 source check: the DPWG cyp3a4_pm/cyp3a4_im interaction edges are valid data. DPWG runs a CYP3A4*22-based metabolizer-phenotype framework (PM/IM/NM) that CPIC does not endorse; the page states that distinction plainly. Cited: Wang 2011 PMID 20386561 (CYP3A4*22 functional), DPWG guideline PharmGKB PA166265421. Definitional satellite of Enzyme:CYP3A4. Final home Phenotype:CYP3A4 <level> metabolizer once namespace registered.)
03:40, 20 May 2026 MDElliottMD talk contribs created page ASRS-v1.1 (Redirect to Adult ADHD Self-Report Scale) Tag: New redirect
03:40, 20 May 2026 MDElliottMD talk contribs created page ASRS (Redirect to Adult ADHD Self-Report Scale) Tag: New redirect
03:26, 20 May 2026 MDElliottMD talk contribs created page Adult ADHD Self-Report Scale (Create encyclopedic page for the ASRS-v1.1 (Adult ADHD Self-Report Scale): development under the WHO (Kessler, Harvard; Adler, NYU), structure (18-item checklist + 6-item Screener), threshold scoring, validation, the DSM-5 update, wiki use as the validated companion to AMAAS, and the NYU/Harvard licensing + mandatory attribution notice. Citations Kessler 2005 PMID 15841682, Kessler 2007 PMID 17623385, Ustun 2017 PMID 28384801, all NCBI-eutils-verified. Describes the instrument; reproduces no...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Category:Pharmacogenomic phenotypes (Create Category:Pharmacogenomic phenotypes per the canonical category-page spec: descriptive history-first lead (the debrisoquine polymorphism, Smith at St Mary's London 1977, Mahgoub 1977 PMID 71400, origin of the poor/extensive metabolizer vocabulary; Weinshilboum 1980 TPMT PMID 7191632; the genotype-to-phenotype harmonisation Caudle 2020 PMID 31647186). Phenotypes-indexed list grouped by gene (26 pages). Notes on scope, About-these-pages, references. Carries Category:Pharmacogenomics paren...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype NUDT15 normal metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype NUDT15 intermediate metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype NUDT15 poor metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype TPMT normal metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype TPMT intermediate metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype TPMT poor metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype UGT1A1 normal metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype UGT1A1 intermediate metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype UGT1A1 poor metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2B6 ultrarapid metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2B6 rapid metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2B6 normal metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2B6 intermediate metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2B6 poor metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2C9 normal metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2C9 intermediate metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2C9 poor metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2C19 ultrarapid metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2C19 rapid metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2C19 normal metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2C19 intermediate metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2C19 poor metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2D6 ultrarapid metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2D6 normal metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
00:32, 20 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2D6 intermediate metabolizer (Sandbox-save pharmacogenomic phenotype page (batch of 25 per Mark 2026-05-19, completing the metabolizer-phenotype set across the 7 enzymes with CPIC phenotype schemes). Definitional satellite of the parent enzyme page: lead defines the phenotype, sections cover genotype basis, population frequency, clinical consequences medicine-by-medicine, and phenocopying where it applies. CPIC/DPWG dosing guidance cited; all PMIDs NCBI-eutils-verified. Final home Phenotype:<NAME> once the namespace is re...)
23:28, 19 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Phenotype CYP2D6 poor metabolizer (Sandbox-save CYP2D6 poor metabolizer phenotype page as the template exemplar for the pharmacogenomic phenotype subpage set (26 pages across 7 enzymes with CPIC phenotype schemes). Definitional satellite page of Enzyme:CYP2D6: lead defines the phenotype + the two-directional clinical principle (activation case vs clearance case); sections for genotype basis, population frequency, clinical consequences, phenocopying. CPIC opioid guideline cited PMID 33387367 (verified). Deliberate deviation fro...)
23:27, 19 May 2026 MDElliottMD talk contribs created page Category:CuratedCategoryPage (Create CuratedCategoryPage maintenance marker (hidden category) per canonical category-page structure)
22:39, 19 May 2026 MDElliottMD talk contribs created page Category:Drug-metabolizing enzymes (Create Category:Drug-metabolizing enzymes: curated index of the 11 enzyme entity pages (8 CYPs + UGT1A1 + TPMT + NUDT15) at their canonical Pharmacopedia: sandbox location, grouped by enzyme family, with scope notes distinguishing enzymes from transporters and non-enzyme variant loci. Parent Category:Pharmacogenomics.)
22:39, 19 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Enzyme NUDT15 (Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...)
22:39, 19 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Enzyme TPMT (Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...)
22:39, 19 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Enzyme UGT1A1 (Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...)
22:39, 19 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Enzyme CYP2E1 (Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...)
22:39, 19 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Enzyme CYP2C9 (Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...)
22:39, 19 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Enzyme CYP2C8 (Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...)
22:39, 19 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Enzyme CYP2B6 (Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...)
22:39, 19 May 2026 MDElliottMD talk contribs created page Pharmacopedia:Pharmacogenomics sandbox/Enzyme CYP1A2 (Consolidate enzyme entity page to canonical Pharmacopedia: sandbox location per Mark 2026-05-19. Full retrofitted version: history-first spine, collapsible-sortable substrate table, comprehensive-tables pointer, all PMIDs NCBI-eutils-verified, zero em-dashes. For CYP2D6/CYP3A4/CYP2C19 this replaces the earlier pre-retrofit draft with the full version; for the other 8 enzymes this is the first save at the canonical location. Resolves a cross-session sandbox-location duplication: the User:MDEll...)
22:11, 19 May 2026 MDElliottMD talk contribs created page User:MDElliottMD/Sandbox/CYP2B6 (Sandbox-save CYP2B6 enzyme entity page (9th pharmacogenomics enzyme page). History-first spine: the rehabilitation of a long-neglected enzyme - Lang/Klein/Zanger Dr. Margarete Fischer-Bosch Institute Stuttgart 2001 polymorphism survey PMID 11470993. 16-row collapsible-sortable substrate table (efavirenz canonical, bupropion probe, methadone, cyclophosphamide/ifosfamide bioactivation, ketamine, others). Full PM/IM/NM/RM/UM phenotype classification per CPIC efavirenz guideline. Major variant *6...)
22:03, 19 May 2026 MDElliottMD talk contribs created page User:MDElliottMD/Sandbox/CYP1A2 (Sandbox-save CYP1A2 enzyme entity page (8th pharmacogenomics enzyme page). History-first spine: Anthony Conney enzyme-induction research (Hoffmann-La Roche, Nutley NJ), 1982 Clowes Memorial Lecture PMID 6814745, AhR induction mechanism. 28-row collapsible-sortable substrate table (clozapine/olanzapine/theophylline/tizanidine headline substrates; caffeine probe; antidepressants, triptans, others). Phenotype section: honest no-PM/IM/NM-bedside-classification (like CYP3A4); variability dominated...)
21:44, 19 May 2026 MDElliottMD talk contribs created page User:MDElliottMD/Sandbox/NUDT15 (Sandbox-save NUDT15 enzyme entity page (7th pharmacogenomics enzyme page, parallel to TPMT). History-first spine: Asan Medical Center Seoul 2014 GWAS in Korean IBD cohort discovering NUDT15 rs116855232 Arg139Cys, Yang 2014 Nat Genet PMID 25108385; Moriyama 2016 Nat Genet mechanism (St. Jude) PMID 26878724; Yang 2015 JCO ALL extension PMID 25624441; Moriyama 2017 Blood diverse-ancestry alleles PMID 28659275; Relling 2019 CPIC TPMT+NUDT15 PMID 30447069; PharmGKB Whirl-Carrillo 2021 PMID 3421602...)
21:35, 19 May 2026 MDElliottMD talk contribs created page User:MDElliottMD/Sandbox/TPMT (Sandbox-save TPMT enzyme entity page (6th pharmacogenomics enzyme page). History-first spine: Weinshilboum & Sladek 1980 Mayo Clinic bimodal-distribution discovery PMID 7191632, one of the foundational pharmacogenetics demonstrations. Lennard 1989 azathioprine-toxicity link PMID 2758725; Krynetski 1995 PNAS TPMT*2 molecular variant PMID 7862671; Loennechen 1998 TPMT*3C PMID 9695718; Relling 2019 CPIC TPMT+NUDT15 thiopurine dosing PMID 30447069. NUDT15 cross-reference section cites Yang 2014 N...)
21:09, 19 May 2026 MDElliottMD talk contribs created page User:MDElliottMD/Sandbox/UGT1A1 (Sandbox-save UGT1A1 enzyme entity page (5th of 10 pharmacogenomics enzyme pages). History-first spine: Gilbert 1901 Paris + Bosma 1995 NEJM Amsterdam closure (UGT1A1*28 promoter TA-repeat discovery). Two CPIC/DPWG guidelines cited: Gammal 2016 CPIC atazanavir PMID 26417955, Hulshof 2023 DPWG irinotecan PMID 36443464. Plus mechanistic refs Iyer 1998 JCI PMID 9466980 (UGT1A1 + SN-38), Innocenti 2004 JCO PMID 15007088 (irinotecan + UGT1A1*28 + neutropenia). Plus Tukey & Strassburg 2000 Annu Rev...)
20:44, 19 May 2026 MDElliottMD talk contribs created page User:MDElliottMD/Sandbox/CYP2C19 (Retrofit CYP2C19 sandbox per Mark 2026-05-19 Option C decision: collapsible-sortable near-complete substrate table (32 rows: PPIs, SSRIs, clopidogrel/proguanil activation, voriconazole, diazepam, mephenytoin probe, carisoprodol, others; tier-tagged major/moderate/minor/partial; activation reactions flagged for clopidogrel and proguanil). Plus Comprehensive substrate and interaction tables pointer section. NOTE: also restored three CPIC-guideline ref definitions (cpic-clopidogrel-2022 PMID 350...)
20:44, 19 May 2026 MDElliottMD talk contribs created page User:MDElliottMD/Sandbox/CYP3A4 (Retrofit CYP3A4 sandbox per Mark 2026-05-19 Option C decision: collapsible-sortable near-complete substrate table (57 rows: benzodiazepines, calcium channel blockers, statins, immunosuppressants, anti-cancer, macrolides, HIV protease inhibitors, DOACs, opioids, antifungals, PDE5 inhibitors, antihistamines, endogenous steroids, others; tier-tagged major/moderate/minor/partial). Plus Comprehensive substrate and interaction tables pointer section naming Flockhart Indiana University, FDA Drug Dev...)
20:44, 19 May 2026 MDElliottMD talk contribs created page User:MDElliottMD/Sandbox/CYP2D6 (Retrofit CYP2D6 sandbox per Mark 2026-05-19 Option C decision: collapsible-sortable near-complete substrate table (49 rows: opioid prodrugs, TCAs, SSRIs/SNRIs, antipsychotics, beta blockers, antiarrhythmics, antiemetics, tamoxifen, atomoxetine, perhexiline, antihistamines, others; tier-tagged major/moderate/minor/partial; activation reactions flagged for codeine/tramadol/risperidone/tamoxifen/venlafaxine). Plus Comprehensive substrate and interaction tables pointer section naming Flockhart In...)
19:31, 19 May 2026 MDElliottMD talk contribs created page User:MDElliottMD/Sandbox/CYP2C9 (Sandbox-save CYP2C9 enzyme entity page (4th of 10 pharmacogenomics enzyme pages). History-first spine: Rettie 1992 Seattle / S-warfarin / CYP2C9. Three CPIC guidelines cited: warfarin 2017 PMID 28198005, phenytoin 2020 PMID 32779747, NSAIDs 2020 PMID 32189324. Plus Rettie 1992 PMID 1581537, Sullivan-Klose 1996 PMID 8873220 (CYP2C9*3 / tolbutamide), Aithal 1999 PMID 10073515 (Lancet warfarin dose / bleeding). All 6 PMIDs NCBI-eutils-verified. Final home Enzyme:CYP2C9 once namespace registered.)