Fluoxetine
From Pharmacopedia
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SSRI, Anxiolytic, Antidepressant
Fluoxetine
Prozac
Fluoxetine is the first of a long line of SSRIs to come. It is remarkable in its extremely long half life and relative lack of withdrawal syndrome. It can also be very useful it helping taper and terminate other SxRI medicines.
anxiolysis, delayed ejaculation, improved mood. anxiety and mood effects are believed to begin 2-3 weeks into supratherapeutic dosing and continue to be increasingly effecting 8-12 weeks out.
2D6 - many
none
Experience
No personal reports yet
1 provider report · avg efficacy 40.0/100 · avg side-effect burden 40.0/100 · 150 patients managed total
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Problems
Anxiety disorders broadly, including panic attacks, social anxiety,
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Start no higher than 10 mg for first dose! Participant may increase by 10 mg every 2-12 weeks, or never increase if they are satisfied with the 10 mg effect.
Effects
Nausea 100% -50.0 (n=2) ~33% -33.0 (n=1)
Common, often improves over 1-2 weeks.
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Sexual dysfunction 100% -83.5 (n=2) — -67.0 (n=1)
Frequent; can persist long-term.
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Interactions
Monitoring
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Summary
Classes
SSRI, Anxiolytic, Antidepressant
Common uses
- Premature ejaculation2.1n=2
- Anxiety disorders broadly1.5n=2
- Panic disorder1.5n=2
- Depressive disorders1.1n=1
- Embarrassment0.5n=3
Pharmacy
Pharmacology
Routes
Oral
Duration
Very long
Half-life
1-4 days (7-15 days for norfluoxetine)
Bioavailability
70-90%
Pregnancy
Category C
Legal status
Rx-only
Purported mechanism
TrkB/BDNF Fluoxetine is a selective serotonin reuptake inhibitor.+1