Fluvoxamine
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SSRI, Antidepressant
Fluvoxamine
Luvox
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Effects
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Interactions
Pharmacogenomic + mechanism interactions
Pharmacogenomic guideline recommendationsCPIC and Dutch Pharmacogenetics Working Group clinical guidelines
CPIC rec 8094271 [Strong]: Initiate therapy with recommended starting dose. CPIC pair-level B (CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants) [PMID 25974703, 37032427]
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CPIC rec 8094275 [Moderate]: Initiate therapy with recommended starting dose. CPIC pair-level B (CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants) [PMID 25974703, 37032427]
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CPIC rec 8094277 [Optional]: Consider a 25-50% lower starting dose and slower titration schedule as compared to normal metabolizers or consider a clinically appropriate alternative antidepressant not predominantly metabolized by CYP2D6. CPIC pair-level B (CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants) [PMID 25974703, 37032427] FDA labeling (Drug Interactions)
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CPIC rec 8094257 [No Recommendation]: No recommendation due to lack of evidence CPIC pair-level B (CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants) [PMID 25974703, 37032427]
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Pharmacokinetic mechanismSubstrate / metabolism relationships from primary literature
FDA Drug Interactions Table: strong index inhibitor of CYP1A2.
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FDA Drug Interactions Table: strong index inhibitor of CYP2C19.
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Inferred from pharmacokinetic dataMaterialised by the inference engine; provenance shown per row
Fluvoxamine inhibits CYP1A2 (inhibitor_strong, intensity 90); Tizanidine is a substrate_major of CYP1A2 (intensity 80). Derived: Tizanidine exposure raised.
Inferred via Enzyme:CYP1A2 (exposure raised)
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Confidence in this inference: is the inferred magnitude sound?overstatedsound
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Fluvoxamine inhibits CYP2C19 (inhibitor_strong, intensity 90); Lansoprazole is a substrate_major of CYP2C19 (intensity 80). Derived: Lansoprazole exposure raised.
Inferred via Enzyme:CYP2C19 (exposure raised)
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Clinical relevance: does this interaction matter in practice?trivialcritical
Confidence in this inference: is the inferred magnitude sound?overstatedsound
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Fluvoxamine inhibits CYP2C19 (inhibitor_strong, intensity 90); Omeprazole is a substrate_major of CYP2C19 (intensity 80). Derived: Omeprazole exposure raised.
Inferred via Enzyme:CYP2C19 (exposure raised)
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Clinical relevance: does this interaction matter in practice?trivialcritical
Confidence in this inference: is the inferred magnitude sound?overstatedsound
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Fluvoxamine inhibits CYP1A2 (inhibitor_strong, intensity 90); Caffeine is a substrate_major of CYP1A2 (intensity 80). Derived: Caffeine exposure raised.
Inferred via Enzyme:CYP1A2 (exposure raised)
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Clinical relevance: does this interaction matter in practice?trivialcritical
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Patient experience
Fluoxetine via Category:Antidepressants exp n/a/5 outcome n/a (n=1) exp 1.0/5 outcome +33.0 (n=1)
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Summary
Classes
SSRI, Antidepressant
Common uses
Pharmacy
Pharmacology
Purported mechanism
Selective serotonin reuptake inhibitor