Isoflurane
Inhalational anesthetic
Isoflurane
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Interactions
Pharmacogenomic + mechanism interactions
Pharmacogenomic guideline recommendationsCPIC and Dutch Pharmacogenetics Working Group clinical guidelines
CPIC rec 8093925 [Strong]: Halogenated volatile anesthetics or the depolarizing muscle relaxant succinylcholine are relatively contraindicated in persons with malignant hyperthermia susceptibility (MHS). They should not be used, except in extraordinary circumstances where the benefits outweigh the risks. In general, alternative anesthetics are widely available and effective in patients with MHS. CPIC pair-level A (RYR1, CACNA1S and Volatile anesthetic agents and Succinylcholine) [PMID 30499100] FDA labeling (Contraindications, Warnings, Clinical Pharmacology)
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CPIC rec 8093925 [Strong]: Halogenated volatile anesthetics or the depolarizing muscle relaxant succinylcholine are relatively contraindicated in persons with malignant hyperthermia susceptibility (MHS). They should not be used, except in extraordinary circumstances where the benefits outweigh the risks. In general, alternative anesthetics are widely available and effective in patients with MHS. CPIC pair-level A (RYR1, CACNA1S and Volatile anesthetic agents and Succinylcholine) [PMID 30499100] FDA labeling (Contraindications, Warnings, Clinical Pharmacology)
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CPIC rec 8093926 [Strong]: Halogenated volatile anesthetics or the depolarizing muscle relaxant succinylcholine are relatively contraindicated in persons with malignant hyperthermia susceptibility (MHS). They should not be used, except in extraordinary circumstances where the benefits outweigh the risks. In general, alternative anesthetics are widely available and effective in patients with MHS. CPIC pair-level A (RYR1, CACNA1S and Volatile anesthetic agents and Succinylcholine) [PMID 30499100] FDA labeling (Contraindications, Warnings, Clinical Pharmacology)
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CPIC rec 8093926 [Strong]: Halogenated volatile anesthetics or the depolarizing muscle relaxant succinylcholine are relatively contraindicated in persons with malignant hyperthermia susceptibility (MHS). They should not be used, except in extraordinary circumstances where the benefits outweigh the risks. In general, alternative anesthetics are widely available and effective in patients with MHS. CPIC pair-level A (RYR1, CACNA1S and Volatile anesthetic agents and Succinylcholine) [PMID 30499100] FDA labeling (Contraindications, Warnings, Clinical Pharmacology)
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Clinical relevance: does this interaction matter in practice?trivialcritical
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CPIC rec 8093927 [Strong]: Clinical findings, family history, further genetic testing and other laboratory data should guide use of halogenated volatile anesthetics or depolarizing muscle relaxants. CPIC pair-level A (RYR1, CACNA1S and Volatile anesthetic agents and Succinylcholine) [PMID 30499100]
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Clinical relevance: does this interaction matter in practice?trivialcritical
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Experience (1 a little, 5 a lot)
Outcome (-100 worst, +100 best)
CPIC rec 8093927 [Strong]: Clinical findings, family history, further genetic testing and other laboratory data should guide use of halogenated volatile anesthetics or depolarizing muscle relaxants. CPIC pair-level A (RYR1, CACNA1S and Volatile anesthetic agents and Succinylcholine) [PMID 30499100]
Rate this interaction. Reports are anonymous and help curate the page.
Clinical relevance: does this interaction matter in practice?trivialcritical
Mechanism description, if it needs work:
Is this row worth surfacing?
Your own experience with this combination:
Experience (1 a little, 5 a lot)
Outcome (-100 worst, +100 best)
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Summary
Classes
Inhalational anesthetic
Common uses
Pharmacy
Pharmacology
Purported mechanism
GABAA potentiator; NMDA antagonist