Tizanidine
Muscle relaxant
Tizanidine
Zanaflex
Experience
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Interactions
Pharmacogenomic + mechanism interactions
Pharmacokinetic mechanismSubstrate / metabolism relationships from primary literature
FDA Drug Interactions Table: sensitive index substrate of CYP1A2.
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Clinical relevance: does this interaction matter in practice?trivialcritical
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Inferred from pharmacokinetic dataMaterialised by the inference engine; provenance shown per row
Fluvoxamine inhibits CYP1A2 (inhibitor_strong, intensity 90); Tizanidine is a substrate_major of CYP1A2 (intensity 80). Derived: Tizanidine exposure raised.
Inferred via Enzyme:CYP1A2 (exposure raised)
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Clinical relevance: does this interaction matter in practice?trivialcritical
Confidence in this inference: is the inferred magnitude sound?overstatedsound
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Experience (1 a little, 5 a lot)
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Summary
Classes
Muscle relaxant
Common uses
Pharmacy
Pharmacology
Purported mechanism
Alpha-2 adrenergic receptor agonist