Midazolam
Benzodiazepine, Sedative-Hypnotic
Midazolam
Versed
Experience
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Effects
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Interactions
Pharmacogenomic + mechanism interactions
Pharmacokinetic mechanismSubstrate / metabolism relationships from primary literature
FDA Drug Interactions Table: sensitive index substrate of CYP3A4.
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Clinical relevance: does this interaction matter in practice?trivialcritical
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Inferred from pharmacokinetic dataMaterialised by the inference engine; provenance shown per row
Phenytoin induces CYP3A4 (inducer_strong, intensity 90); Midazolam is a substrate_major of CYP3A4 (intensity 80). Derived: Midazolam exposure lowered.
Inferred via Enzyme:CYP3A4 (exposure lowered)
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Clinical relevance: does this interaction matter in practice?trivialcritical
Confidence in this inference: is the inferred magnitude sound?overstatedsound
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Experience (1 a little, 5 a lot)
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Rifampin induces CYP3A4 (inducer_strong, intensity 90); Midazolam is a substrate_major of CYP3A4 (intensity 80). Derived: Midazolam exposure lowered.
Inferred via Enzyme:CYP3A4 (exposure lowered)
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Clinical relevance: does this interaction matter in practice?trivialcritical
Confidence in this inference: is the inferred magnitude sound?overstatedsound
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Experience (1 a little, 5 a lot)
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Clarithromycin inhibits CYP3A4 (inhibitor_strong, intensity 90); Midazolam is a substrate_major of CYP3A4 (intensity 80). Derived: Midazolam exposure raised.
Inferred via Enzyme:CYP3A4 (exposure raised)
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Clinical relevance: does this interaction matter in practice?trivialcritical
Confidence in this inference: is the inferred magnitude sound?overstatedsound
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Experience (1 a little, 5 a lot)
Outcome (-100 worst, +100 best)
Itraconazole inhibits CYP3A4 (inhibitor_strong, intensity 90); Midazolam is a substrate_major of CYP3A4 (intensity 80). Derived: Midazolam exposure raised.
Inferred via Enzyme:CYP3A4 (exposure raised)
Rate this interaction. Reports are anonymous and help curate the page.
Clinical relevance: does this interaction matter in practice?trivialcritical
Confidence in this inference: is the inferred magnitude sound?overstatedsound
Mechanism description, if it needs work:
Is this row worth surfacing?
Your own experience with this combination:
Experience (1 a little, 5 a lot)
Outcome (-100 worst, +100 best)
Carbamazepine induces CYP3A4 (inducer_strong, intensity 90); Midazolam is a substrate_major of CYP3A4 (intensity 80). Derived: Midazolam exposure lowered.
Inferred via Enzyme:CYP3A4 (exposure lowered)
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Clinical relevance: does this interaction matter in practice?trivialcritical
Confidence in this inference: is the inferred magnitude sound?overstatedsound
Mechanism description, if it needs work:
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Experience (1 a little, 5 a lot)
Outcome (-100 worst, +100 best)
Verapamil inhibits CYP3A4 (inhibitor_moderate, intensity 55); Midazolam is a substrate_major of CYP3A4 (intensity 80). Derived: Midazolam exposure raised.
Inferred via Enzyme:CYP3A4 (exposure raised)
Rate this interaction. Reports are anonymous and help curate the page.
Clinical relevance: does this interaction matter in practice?trivialcritical
Confidence in this inference: is the inferred magnitude sound?overstatedsound
Mechanism description, if it needs work:
Is this row worth surfacing?
Your own experience with this combination:
Experience (1 a little, 5 a lot)
Outcome (-100 worst, +100 best)
Erythromycin inhibits CYP3A4 (inhibitor_moderate, intensity 55); Midazolam is a substrate_major of CYP3A4 (intensity 80). Derived: Midazolam exposure raised.
Inferred via Enzyme:CYP3A4 (exposure raised)
Rate this interaction. Reports are anonymous and help curate the page.
Clinical relevance: does this interaction matter in practice?trivialcritical
Confidence in this inference: is the inferred magnitude sound?overstatedsound
Mechanism description, if it needs work:
Is this row worth surfacing?
Your own experience with this combination:
Experience (1 a little, 5 a lot)
Outcome (-100 worst, +100 best)
Fluconazole inhibits CYP3A4 (inhibitor_moderate, intensity 55); Midazolam is a substrate_major of CYP3A4 (intensity 80). Derived: Midazolam exposure raised.
Inferred via Enzyme:CYP3A4 (exposure raised)
Rate this interaction. Reports are anonymous and help curate the page.
Clinical relevance: does this interaction matter in practice?trivialcritical
Confidence in this inference: is the inferred magnitude sound?overstatedsound
Mechanism description, if it needs work:
Is this row worth surfacing?
Your own experience with this combination:
Experience (1 a little, 5 a lot)
Outcome (-100 worst, +100 best)
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Summary
Classes
Benzodiazepine, Sedative-Hypnotic
Common uses
Pharmacy
Pharmacology
Purported mechanism
GABAA positive allosteric modulator