Caffeine
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Xanthine, Stimulant
Caffeine
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Interactions
Pharmacogenomic + mechanism interactions
Pharmacokinetic mechanismSubstrate / metabolism relationships from primary literature
FDA Drug Interactions Table: sensitive index substrate of CYP1A2.
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Clinical relevance: does this interaction matter in practice?trivialcritical
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Inferred from pharmacokinetic dataMaterialised by the inference engine; provenance shown per row
Fluvoxamine inhibits CYP1A2 (inhibitor_strong, intensity 90); Caffeine is a substrate_major of CYP1A2 (intensity 80). Derived: Caffeine exposure raised.
Inferred via Enzyme:CYP1A2 (exposure raised)
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Clinical relevance: does this interaction matter in practice?trivialcritical
Confidence in this inference: is the inferred magnitude sound?overstatedsound
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Summary
Classes
Xanthine, Stimulant
Common uses
Pharmacy
Pharmacology
Purported mechanism
Adenosine receptor antagonist
“Pendell's corner
Caffeine is a central nervous system stimulant, a cardiac stimulant, a respiratory stimulant, and a diuretic. Caffeine is addictive. Withdrawal symptoms typically include irritability, fatigue, and headaches, sometimes severe.
— Dale Pendell, Pharmako/Dynamis, p. 29