CBN
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Cannabinoid (minor), phytocannabinoid, THC oxidation product
Cannabinol
Cannabinol (CBN) is a minor phytocannabinoid present in small concentrations in fresh cannabis and accumulating in stored, oxidized, or heat-degraded plant material as a non-enzymatic oxidation product of delta-9-tetrahydrocannabinol. It binds the CB1 receptor with roughly one-tenth the affinity of THC and is at most very weakly psychoactive on its own. CBN is often described in popular sources as a "sleep cannabinoid", but the controlled evidence for a hypnotic effect is sparse; the sedation associated with old or degraded cannabis is more likely the combined contribution of CBN, other oxidation products, and shifts in terpene profile than CBN alone.[1]
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Summary
Classes
Cannabinoid (minor), phytocannabinoid, THC oxidation product
Common uses
Pharmacy
Pharmacology
Purported mechanism
Weak CB1 partial agonist; weak CB2 partial agonist; multiple secondary targets.
- ↑ Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 2011 Aug;163(7):1344-64. PMID: 21749363.