Fluoxetine

fluoxetine

Prozac

Fluoxetine is the first of a long line of SSRIs to come. It is remarkable in its extremely long half life and relative lack of withdrawal syndrome. It can also be very useful it helping taper and terminate other SxRI medicines.

Experience

👥 No personal reports yet

⚕ 1 provider report · avg efficacy 40.0/100 · avg side-effect burden 40.0/100 · 150 patients managed total

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Problems

Anxiety disorders broadly, including panic attacks, social anxiety,

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Titration strategies

Start no higher than 10 mg for first dose! Participant may increase by 10 mg every 2-12 weeks, or never increase if they are satisfied with the 10 mg effect.

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Effects

anxiolysis, delayed ejaculation, improved mood (?)Nausea, GI upset,

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Interactions

2D6 - many

Monitoring

none

Relevant anecdote

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Relevant Literature

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Summary

Common uses

• Depressive disorders★★★★★★★★★★★★★★★1.0n=1×
• Anxiety disorders broadly★★★★★★★★★★★★★★★4.0n=2×
• Panic disorder★★★★★★★★★★★★★★★1.3n=2×
• Social anxiety disorder★★★★★★★★★★★★★★★1.0n=1×
• Obsessive-compulsive disorder★★★★★★★★★★★★★★★2.0n=1×

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Pharmacy

Pharmacology

Routes

Oral

Duration

Very long

Half-life

1-4 days (7-15 days for norfluoxetine)

Bioavailability

70-90%

Pregnancy

Category C

Legal status

Rx-only

Purported mechanism

TrkB/BDNF