Fremanezumab
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Anti-CGRP ligand monoclonal antibody
Fremanezumab
Ajovy
Fremanezumab (brand name Ajovy) is an anti-CGRP monoclonal antibody approved in 2018 for migraine prevention. It is unique in offering both monthly and quarterly dosing options.
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Summary
Classes
Anti-CGRP ligand monoclonal antibody
Common uses
Preventive treatment of migraine in adults (episodic and chronic)
Pharmacy
Starting dose
225 mg SC monthly, or 675 mg SC every 3 months (quarterly)
Preparations
225 mg/1.5 mL prefilled syringe or autoinjector
US FDA Max
675 mg/quarter
Pharmacology
Routes
Subcutaneous
Onset
Over weeks
Duration
Monthly or quarterly dosing
Half-life
~31 days
Bioavailability
Not formally established
Pregnancy
Limited data; avoid
Legal status
Rx
Purported mechanism
Humanized IgG2 monoclonal antibody binding both isoforms of CGRP peptide