Percodan

Opioid analgesic, NSAID (aspirin), Schedule II controlled substance, Fixed-dose combination

Oxycodone / Aspirin

Percodan

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Summary

Classes

Opioid analgesic, NSAID (aspirin), Schedule II controlled substance, Fixed-dose combination

Common uses

Moderate to moderately severe acute pain (less commonly prescribed than acetaminophen-opioid combinations due to NSAID GI risk)▲0▼

Pharmacy

Starting dose

1 tablet (4.8355 mg oxycodone / 325 mg aspirin) PO every 6 hours as needed

Preparations

4.8355 mg oxycodone / 325 mg aspirin tablets

US FDA Max

Aspirin GI/bleeding-limited; oxycodone titrated to effect

Pharmacology

Routes

Oral

Onset

15-30 minutes

Duration

4-6 hours

Half-life

Oxycodone 3-5 hours; aspirin (acetyl group) 15-20 minutes, salicylate 2-3 hours at therapeutic doses

Bioavailability

Oxycodone 60-87%; aspirin 50-75%

Pregnancy

Avoid; aspirin teratogenicity concerns plus opioid neonatal withdrawal.^{[citation needed]}

Legal status

Schedule II controlled substance in US

Purported mechanism

Oxycodone provides μ-opioid receptor agonism for opioid analgesia; aspirin (acetylsalicylic acid) provides non-selective COX-1/COX-2 inhibition with anti-inflammatory and antiplatelet effects in addition to analgesic.▲0▼ Falling out of favor for acute pain due to aspirin's GI bleeding and antiplatelet effects compared with acetaminophen-opioid combinations; still used in selected indications.