Penicillin V
Penicillin V (phenoxymethylpenicillin)
Pen-V, Veetids (mostly generic)
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Summary
Common uses
Streptococcal pharyngitis0, Rheumatic fever secondary prophylaxis0, Dental procedural prophylaxis (when appropriate)0, Post-splenectomy pneumococcal prophylaxis (children)0, Erysipelas / cellulitis (penicillin-susceptible)0
Pharmacy
Starting dose
250-500 mg PO every 6-8 hours
Preparations
250 mg, 500 mg tablets; 125 mg/5 mL, 250 mg/5 mL suspension
US FDA Max
2 g/d typical
Pharmacology
Routes
Oral
Onset
Hours
Duration
6-8 hours
Half-life
~30-60 minutes[1]
Bioavailability
~60% (oral; phenoxymethyl modification makes it acid-stable, unlike penicillin G which is destroyed by gastric acid)[1]
Pregnancy
Generally considered safe; widely used.[citation needed]
Legal status
Rx-only in US
Purported mechanism
Penicillin V binds penicillin-binding proteins (PBPs), inhibiting transpeptidation of peptidoglycan cross-links and producing osmotic lysis of growing organisms.0 Acid-stable oral natural penicillin with retained activity against Group A Streptococcus, oral streptococci, and Treponema; narrow-spectrum profile preserves microbiome and remains the first-line for confirmed strep pharyngitis because of demonstrated long-term effectiveness, low cost, and avoidance of broader-spectrum collateral damage[1].
References
- ↑ 1.0 1.1 1.2 FDA Prescribing Information, Pen-V (penicillin V potassium), Eon, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050442s019lbl.pdf