Albuterol
Unchecked
Albuterol
Ventolin, ProAir, Proventil, AccuNeb
Experience
No personal reports yet
No clinical reports yet
Log in to add your own experience.
Problems
No problems yet. Be the first to suggest one.
+ Add a problemTitration strategies
No titration strategies yet. Be the first to suggest one.
Effects
No effects listed yet. Be the first to suggest one.
Relevant anecdote
No anecdotes yet. Share a relevant one.
Relevant Literature
No literature entries yet.
Log in to submit relevant literature.
Summary
Common uses
Asthma rescue0, Acute bronchospasm0, Exercise-induced bronchospasm0, COPD exacerbation0
Pharmacy
Starting dose
MDI 90 mcg/puff, 2 puffs q4-6h prn; nebulized 2.5 mg in 3 mL saline q4-6h
Preparations
MDI 90 mcg/puff; nebulizer solution 0.083% (2.5 mg/3 mL), 0.5%, 0.021%, 0.042%; syrup 2 mg/5 mL; 2 mg, 4 mg tablets; 4 mg, 8 mg ER
US FDA Max
12 inhalations/d (rescue); higher for severe exacerbation under monitoring
Pharmacology
Routes
Inhaled (MDI, nebulized), Oral
Onset
Inhaled: 5-15 minutes; PO: 30 minutes
Duration
4-6 hours
Half-life
4-6 hours (inhaled and PO)[1]
Bioavailability
~10% inhaled reaches systemic circulation; ~50% PO[1]
Pregnancy
Preferred SABA in pregnancy; benefits of asthma control outweigh limited risks.[citation needed]
Legal status
Rx-only in US
Purported mechanism
Albuterol is a short-acting selective β2-adrenergic agonist; receptor binding raises intracellular cAMP via Gs-protein-coupled adenylyl cyclase activation, relaxing bronchial smooth muscle within minutes.0 At higher doses β2 selectivity is lost, producing β1 effects (tachycardia, tremor) and hypokalemia from intracellular potassium shift[1].
References
[edit | edit source]- ↑ 1.0 1.1 1.2 FDA Prescribing Information, Ventolin HFA (albuterol sulfate), GlaxoSmithKline, current revision. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020983s039lbl.pdf