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Drilldown: Medicines

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Medicines > generic: None & bioavailability : ~75% or ~80% (oral)'"`UNIQ--ref-00000027-QINU`"'

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generic: (Click arrow to add another value)
brand:
Trintellix (US), Brintellix (formerly) (1)
classes:
Multimodal antidepressant: SERT inhibitor + 5HT1A agonist + 5HT1B partial agonist + 5HT3/5HT7 antagonist (1)
mechanism:
None (1)
uses:
Major depressive disorder in adults (FDA-approved 2013). Notable for evidence of cognitive benefit (processing speed) that distinguishes it from other antidepressants. (1)
starting dose:
10 mg PO once daily; may increase to 20 mg as tolerated, or decrease to 5 mg if needed (1)
preparations:
5 mg, 10 mg, 20 mg tablets (1)
fda max:
20 mg/d (1)
routes:
Oral (1)
onset:
Typical antidepressant 4-6 week onset (1)
duration:
Daily dosing (1)
halflife:
~66 hours (1)
bioavailability: (Click arrow to add another value)
pregnancy:
Limited data; weigh benefits/risks (1)
legal:
Rx (1)
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