Drilldown: Medicines

5-HTP (1) · 7-Hydroxymitragynine (1) · Acacia confusa (1) · Adrafinil (1) · Amanita muscaria (1) · Aniracetam (1) · Ayahuasca (1) · Blue lotus (1) · Bromantane (1) · Calea zacatechichi (1) · Coluracetam (1) · Datura (1) · Harmaline (1) · Harmine (1) · Hawaiian Baby Woodrose (1) · Iboga (1) · Kava (1) · Kratom (1) · L-Theanine (1) · Mitragynine (1) · Morning Glory (1) · Myristicin (1) · Noopept (1) · Oxiracetam (1) · Peyote (1) · Phenibut (1) · Phenylpiracetam (1) · Piracetam (1) · Pramiracetam (1) · Psilocybin mushrooms (1) · Salvia divinorum (1) · San Pedro cactus (1) · Semax (1) · Syrian rue (1) · Tetrahydroharmine (1) · Yopo (1)

None (36)

Research material · Classic Psychedelic · Stimulant · Opioid · Sedative-Hypnotic · Phenethylamine · Tryptamine · Benzodiazepine · Botanical · [[:Category:Antihypertensives|Antihypertensive]] · Dissociative · Anticonvulsant · Antidepressant · Plant Medicine · Analgesic · Antipsychotic · Antiparkinsonian · Empathogen · Neuroleptic · Cathinone

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ACTH analogue; BDNF upregulator (1) · AMPA modulator; catecholaminergic (1) · AMPA receptor modulator (1) · AMPA receptor positive allosteric modulator (2) · AMPA/NMDA modulator; NGF/BDNF upregulation (1) · Apomorphine and nuciferine; dopaminergic activity (1) · Contains atropine, scopolamine, hyoscyamine (1) · Contains bufotenin and DMT (1) · Contains harmine, harmaline, tetrahydroharmine (1) · Contains ibogaine; kappa-opioid agonist (1) · Contains LSA (2) · Contains mescaline (2) · Contains muscimol and ibotenic acid (1) · Contains psilocybin and psilocin (1) · Contains salvinorin A (1) · DMT + MAOI (harmine/harmaline); 5-HT2A agonist (1) · DMT-containing plant used in psychedelic preparations (1) · Dopamine and serotonin reuptake inhibitor; actoprotector (1) · GABAB agonist; alpha-2-delta calcium channel ligand (1) · Glutamate receptor antagonist; GABA modulator (1) · High-affinity choline uptake enhancer (2) · Kavalactones; GABAA modulator; sigma receptor activity (1) · Mechanism incompletely understood (1) · Mitragynine/7-hydroxymitragynine; mu-opioid partial agonist (1) · Partial MAOI; anticholinergic effects (1) · Partial mu-opioid receptor agonist; alpha-2 agonist (1) · Potent mu-opioid receptor agonist (1) · Prodrug of modafinil (1) · Reversible MAO-A inhibitor; beta-carboline (1) · Reversible MAO-A inhibitor; NMDA antagonist; beta-carboline (1) · Serotonin precursor; 5-hydroxytryptophan (1) · Weak serotonin reuptake inhibitor; beta-carboline (1)

None (36)

None (36)

None (36)

None (36)

None (36)

None (36)

None (36)

None (36)

None · 100% (IV) · ~100% from subcutaneous depot · ~80% (oral)'"`UNIQ--ref-00000027-QINU`"' · 70–90% (oral) · ~100% (oral)'"`UNIQ--ref-0000001C-QINU`"' · ~50% (oral)'"`UNIQ--ref-00000021-QINU`"' · ~95% · '''Saturable''' via the LAT-1 amino-acid transporter, producing nonlinear pharmacokinetics: ~60% at 300 mg single dose, falling to ~35% at 1200 mg single dose'"`UNIQ--ref-0000002A-QINU`"' · 10-20% (oral; reduced by food, calcium, antacids, PPIs, tea/coffee; enhanced by ascorbate) · 100% (IV); essentially complete (oral) · 100% (IV); rapidly neutralized by gastric acid (oral) · 16-21% capsule, 25% suspension (oral; iron and antacids reduce absorption substantially)'"`UNIQ--ref-000009E5-QINU`"' · 25 mg: ~29%; 50 mg: ~35%; food reduces absorption'"`UNIQ--ref-00000C4F-QINU`"' · 30-40% (oral; increases with repeated dosing as gastric pH rises)'"`UNIQ--ref-000000DF-QINU`"' · 40-45% (oral; not significantly affected by food)'"`UNIQ--ref-0000025C-QINU`"' · 40-80% (oral); reduced by food, calcium, iron, PPIs, fiber; take fasting with water'"`UNIQ--ref-00000037-QINU`"' · 42-58% (oral; dose-dependent)'"`UNIQ--ref-00000AEF-QINU`"' · 50-60% (oral; decreased with food, but food given anyway for GI tolerance)'"`UNIQ--ref-00000019-QINU`"' · 60-70% PO at low doses; saturable at high doses (parenteral routes preferred above 15-25 mg/week)'"`UNIQ--ref-000007C9-QINU`"'

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None (36)

None (36)