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Medicines > classes : 5HT2A/D2 antagonist with proposed differential pre/post-synaptic D2 activity or Cathinone

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generic:
None (1) · 3-MMC (1) · Butylone (1) · Cathinone (1) · Ephylone (1) · Ethcathinone (1) · Ethylone (1) · Hexedrone (1) · Mephedrone (1) · Methcathinone (1) · Methylone (1) · Mexedrone (1) · N-Ethylhexedrone (1) · N-Ethylpentedrone (1) · Pentedrone (1)
brand:
None (14) · Caplyta (1)
classes: (Click arrow to add another value)
mechanism:
None (1) · Cathinone analogue; monoamine reuptake inhibitor (2) · Monoamine releasing agent (4) · Monoamine releasing agent; active ingredient in khat (1) · Norepinephrine and dopamine releasing agent (1) · Norepinephrine/dopamine releasing agent (1) · Norepinephrine/dopamine reuptake inhibitor (1) · Serotonin releasing agent; monoamine reuptake inhibitor (1) · Serotonin/norepinephrine/dopamine releasing agent (3)
uses:
None (14) · Schizophrenia (FDA-approved Dec 2019). Bipolar depression as monotherapy or adjunct to lithium/valproate (FDA-approved Dec 2021). (1)
starting dose:
None (14) · 42 mg PO once daily with food (no titration) (1)
preparations:
None (14) · 42 mg capsules (1)
fda max:
None (14) · 42 mg/d (1)
routes:
None (14) · Oral (1)
onset:
None (14) · Antipsychotic effect over weeks (1)
duration:
None (14) · Daily dosing (1)
halflife:
None (14) · ~18 hours (terminal) (1)
bioavailability:
None (14) · Limited but adequate; take with food (1)
pregnancy:
None (14) · Limited data; National Pregnancy Registry for Atypical Antipsychotics (1)
legal:
None (14) · Rx (1)

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