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Drilldown: Medicines

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Medicines > classes : 5HT2A or Benzodiazepine or Classic Psychedelic

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generic:
brand:
None (78) · Dalmane (1) · Delysid (historical, Sandoz, withdrawn 1965) (1) · Doral (1) · Halcion (1) · Lexotan (1) · Librium (1) · Mogadon (1) · Onfi (1) · ProSom (1) · Restoril (1) · Rexulti (1) · Rohypnol (1) · Serax (1) · Tranxene (1) · Versed (1) · Xanax (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (26) · GABAA positive allosteric modulator (18) · Potent 5-HT2A agonist (5) · LSD analogue; 5-HT2A agonist (4) · Prodrug of LSD; 5-HT2A agonist (4) · Contains LSA (2) · Contains mescaline (2)
uses:
None (92) · Schizophrenia (FDA-approved 2015). Adjunctive treatment of major depressive disorder (2015). '''Agitation associated with dementia due to Alzheimer disease''' (FDA-approved May 2023, first agent specifically approved for this problem). Investigational for PTSD (combined with sertraline). (1) · '"`UNIQ--vote-00000069-QINU`"', '"`UNIQ--vote-0000006A-QINU`"', '"`UNIQ--vote-0000006B-QINU`"' (1)
starting dose:
None (92) · 0.25 mg (1) · Schizophrenia: 1 mg PO daily × 4 days, then 2 mg daily × 3 days, then 4 mg daily. MDD adjunct: 0.5-1 mg daily, increase to 2 mg max. AD agitation: 0.5 mg daily, titrate to 2-3 mg daily. (1)
preparations:
None (92) · 0.25 mg, 0.5 mg, 1 mg, 2 mg tablets (immediate-release and orally disintegrating); 0.5 mg, 1 mg, 2 mg, 3 mg extended-release tablets; 1 mg/mL oral concentrate (1) · 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, 4 mg tablets (1)
fda max:
None (92) · 10 mg/d (1) · 4 mg/d (schizophrenia); 3 mg/d (AD agitation); 3 mg/d (MDD adjunct) (1)
routes:
None (91) · Oral (3)
onset:
None (91) · 30-60 min (immediate-release); 1-2 h (extended-release) (1) · 30–60 minutes (1) · Weeks for psychosis/depression; AD agitation benefit emerges over weeks (1)
duration:
None (91) · 6 h (immediate-release); ~11 h (extended-release) (1) · 8–12 hours (1) · Daily dosing (1)
halflife:
None (91) · 11-13 h (immediate-release); 11-16 h (extended-release) (1) · 3–5 hours (1) · ~91 hours (1)
bioavailability:
None (91) · 70–90% (oral) (1) · 80-90% oral (1) · ~95% (1)
pregnancy:
None (91) · Category D'"`UNIQ--ref-0000006C-QINU`"' (1) · Limited data; National Pregnancy Registry available (1) · Not established (1)
legal:
None (91) · Rx (1) · Schedule I (United States) (1) · Schedule IV (US) (1)

Showing below up to 94 results in range #1 to #94.

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