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Drilldown: Medicines

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Medicines > classes : 5HT2A or Classic Psychedelic or Neuroleptic

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generic:
brand:
None (69) · Clozaril (1) · Delysid (historical, Sandoz, withdrawn 1965) (1) · Fanapt (1) · Geodon (1) · Inapsine (1) · Invega (1) · Latuda (1) · Loxitane (1) · Mellaril (1) · Moban (1) · Navane (1) · Orap (1) · Prolixin (1) · Rexulti (1) · Saphris (1) · Stelazine (1) · Thorazine (1) · Trilafon (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (26) · Potent 5-HT2A agonist (5) · LSD analogue; 5-HT2A agonist (4) · Phenothiazine D2 antagonist (4) · Prodrug of LSD; 5-HT2A agonist (4) · Contains LSA (2) · Contains mescaline (2)
uses:
None (86) · Schizophrenia (FDA-approved 2015). Adjunctive treatment of major depressive disorder (2015). '''Agitation associated with dementia due to Alzheimer disease''' (FDA-approved May 2023, first agent specifically approved for this problem). Investigational for PTSD (combined with sertraline). (1)
starting dose:
None (86) · Schizophrenia: 1 mg PO daily × 4 days, then 2 mg daily × 3 days, then 4 mg daily. MDD adjunct: 0.5-1 mg daily, increase to 2 mg max. AD agitation: 0.5 mg daily, titrate to 2-3 mg daily. (1)
preparations:
None (86) · 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, 4 mg tablets (1)
fda max:
None (86) · 4 mg/d (schizophrenia); 3 mg/d (AD agitation); 3 mg/d (MDD adjunct) (1)
routes:
None (85) · Oral (2)
onset:
None (85) · 30–60 minutes (1) · Weeks for psychosis/depression; AD agitation benefit emerges over weeks (1)
duration:
None (85) · 8–12 hours (1) · Daily dosing (1)
halflife:
None (85) · 3–5 hours (1) · ~91 hours (1)
bioavailability:
None (85) · 70–90% (oral) (1) · ~95% (1)
pregnancy:
None (85) · Limited data; National Pregnancy Registry available (1) · Not established (1)
legal:
None (85) · Rx (1) · Schedule I (United States) (1)

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