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Drilldown: Medicines

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Medicines > classes : Anticholinergic or Empathogen or dissociative

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generic:
brand:
None (35) · Akineton (1) · Artane (1) · Cogentin (1) · DXM (1) · DXO (1) · Spravato (1) · Transderm (1)
classes: (Click arrow to add another value)
mechanism:
None (1) · Active metabolite of DXM; NMDA antagonist (1) · Contains salvinorin A (1) · Kappa-opioid agonist; NMDA antagonist; SERT/DAT/NET inhibitor (1) · Kappa-opioid receptor agonist (1) · MAO inhibitor; monoamine releasing agent (1) · MAO inhibitor; serotonin releasing agent (1) · Monoamine releasing agent (3) · Monoamine releasing agent; 5-HT2A agonist (1) · Monoamine releasing agent; serotonergic at higher doses (1) · Muscarinic receptor antagonist (4) · Muscarinic receptor antagonist; dopamine reuptake inhibitor (1) · NMDA antagonist (3) · NMDA antagonist; endogenous opioid releaser (1) · NMDA antagonist; fluorinated ketamine analogue (1) · NMDA antagonist; kappa-opioid agonist (1) · NMDA antagonist; ketamine analogue (1) · NMDA antagonist; more stimulating than PCP (1) · NMDA antagonist; opioid agonist (1) · NMDA antagonist; potent opioid agonist (1) · NMDA antagonist; SERT inhibitor; sigma-1 agonist (1) · NMDA antagonist; sigma receptor agonist (2) · NMDA antagonist; sigma receptor agonist; dopaminergic (1) · NMDA antagonist; sigma-1 agonist; serotonin reuptake inhibitor (1) · Selective M1 muscarinic antagonist (1) · Serotonin releasing agent (2) · Serotonin releasing agent; 5-HT2A agonist (3) · Serotonin/dopamine/norepinephrine releasing agent; 5-HT2A agonist (1) · Serotonin/norepinephrine/dopamine releasing agent (3)
uses:
None (41) · Treatment-resistant depression (TRD) in adults, as adjunct to oral antidepressant (FDA-approved March 2019). Depressive symptoms in adults with MDD with acute suicidal ideation or behavior (FDA-approved Aug 2020). (1)
starting dose:
None (41) · Induction (TRD): 56 mg intranasal twice weekly × 4 weeks. Maintenance: 56-84 mg once weekly × 4 weeks, then 56-84 mg every 1-2 weeks. For acute suicidality: 84 mg twice weekly × 4 weeks. Administered under medical supervision in REMS-certified site. (1)
preparations:
None (41) · 28 mg/device (each dose uses 2 devices) (1)
fda max:
None (41) · 84 mg per session (1)
routes:
None (41) · Intranasal (under direct medical supervision) (1)
onset:
None (41) · Within hours of first administration (1)
duration:
None (41) · Acute effect ~24 hours; cumulative effect builds with repeated dosing (1)
halflife:
None (41) · ~7-12 hours (1)
bioavailability:
None (41) · ~48% intranasal (1)
pregnancy:
None (41) · Avoid; may cause fetal harm (1)
legal:
None (41) · Rx, Schedule III (US). REMS program required. (1)

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