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Drilldown: Medicines

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Medicines > classes : Anticonvulsant or Botanical or Neuroactive steroid

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generic:
None (2)
brand:
None (23) · Aptiom (1) · Banzel (1) · Briviact (1) · Cerebyx (1) · Depakote (1) · Diacomit (1) · Dilantin (1) · Epidiolex (1) · Felbatol (1) · Fintepla (1) · Fycompa (1) · Gabitril (1) · Luminal (1) · Onfi (1) · Sabril (1) · Vimpat (1) · Xcopri (1) · Zarontin (1) · Zonegran (1) · Zulresso (1) · Zurzuvae (1)
classes: (Click arrow to add another value)
mechanism:
Contains LSA (2) · Contains mescaline (2) · Sodium channel blocker (2)
uses:
None (42) · Postpartum depression (PPD) in adults (1) · Postpartum depression (PPD) in adults (FDA-approved 2023) (1)
starting dose:
None (42) · 50 mg PO once daily with fatty food in the evening × 14 days (1) · Single 60-hour continuous IV infusion: 30 mcg/kg/h × 4h → 60 mcg/kg/h × 20h → 90 mcg/kg/h × 28h → 60 mcg/kg/h × 4h → 30 mcg/kg/h × 4h (1)
preparations:
None (42) · 100 mg/20 mL vial, single-use (1) · 20 mg, 25 mg, 30 mg capsules (1)
fda max:
None (42) · 50 mg/d × 14 d (1) · Single 60-hour course (1)
routes:
None (42) · Intravenous (continuous infusion in a REMS-certified facility) (1) · Oral (1)
onset:
None (42) · Antidepressant effect within hours of infusion start; sustained at 30 days (1) · Day 3 of dosing in trials; sustained through day 45 (1)
duration:
None (42) · 14-day course; effect persists after discontinuation in trials (1) · Single infusion course (1)
halflife:
None (42) · ~16-23 hours (1) · ~9 hours (terminal) (1)
bioavailability:
None (42) · 100% (IV) (1) · Adequate (food-dependent, must take with fatty meal) (1)
pregnancy:
None (42) · Limited data; avoid in pregnancy. Lactation: present in milk; consider risks (1) · Medicine is structurally identical to endogenous allopregnanolone; pregnancy considerations relate to breastfeeding during/after infusion. Limited data; brief interruption of breastfeeding considered (1)
legal:
None (42) · Rx, Schedule IV (US) (1) · Rx; REMS program required (excessive sedation/loss of consciousness during infusion) (1)

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