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Medicines > classes : Antidepressant or [[:Category:Antimuscarinics|Antimuscarinic (M3-selective)]] & routes: Oral

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generic:
Duloxetine (1) · Sertraline (1) · Solifenacin (1)
brand:
Cymbalta, Drizalma Sprinkle, Irenka, Yentreve (1) · Vesicare (1) · Zoloft (1)
classes: (Click arrow to add another value)
mechanism:
Serotonin–norepinephrine reuptake inhibition (balanced) (1) · TrkB/BDNF'"`UNIQ--ref-00000084-QINU`"' '"`UNIQ--vote-00000085-QINU`"' (1) · '"`UNIQ--vote-00000DFA-QINU`"' CYP3A4 substrate; QT-interval prolongation has been reported at higher doses. Like other antimuscarinics, contributes to cumulative anticholinergic burden in older adults'"`UNIQ--ref-00000DFB-QINU`"'. (1)
uses:
None (1) · Depression, anxiety, neuropathic pain, fibromyalgia, chronic musculoskeletal pain (1) · '"`UNIQ--vote-00000DFC-QINU`"', '"`UNIQ--vote-00000DFD-QINU`"' (1)
starting dose:
None (1) · 25 mg (1) · 5 mg PO once daily; titrate to 10 mg after 2 weeks if needed (1)
preparations:
None (1) · 25 mg, 50 mg, 100 mg tablets; oral concentrate 20 mg/mL (1) · 5, 10 mg tablets (1)
fda max:
None (1) · 10 mg/d (5 mg if severe renal or moderate hepatic impairment, or strong CYP3A4 inhibitors) (1) · 200 mg/d (1)
routes: (Click arrow to add another value)
onset:
Anxiolysis classically 3-4 weeks, continuing improvement to 8-12 weeks (1) · Mood: 2–4 weeks. Pain: often within 1–2 weeks. (1) · Symptom improvement within 1-2 weeks (1)
duration:
24 hours (1) · Chronic daily dosing (1) · Long (1)
halflife:
~12 hours (1) · ~26 h (sertraline; range 13-45 h, longer in females); ~62-104 h (N-desmethylsertraline, weakly active) (1) · ~45-68 hours'"`UNIQ--ref-00000DFE-QINU`"' (1)
bioavailability:
Absolute bioavailability not precisely characterized; food modestly increases exposure (1) · ~50% (highly variable) (1) · ~90% (oral)'"`UNIQ--ref-00000DFF-QINU`"' (1)
pregnancy:
Category C (1) · Category C'"`UNIQ--ref-0000008F-QINU`"' (1) · Limited data.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
Rx-only (1) · Rx-only in US (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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