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Medicines > classes : Antidepressant or [[:Category:Antioxidants|Antioxidant]] & routes: Oral

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generic:
Ascorbic acid (vitamin C) (1) · Duloxetine (1) · Sertraline (1) · Vitamin E (α-tocopherol; mixed natural and synthetic forms) (1)
brand:
Cymbalta, Drizalma Sprinkle, Irenka, Yentreve (1) · Generic; huge OTC presence (1) · Generic; many OTC formulations (1) · Zoloft (1)
classes: (Click arrow to add another value)
mechanism:
None (2) · Serotonin–norepinephrine reuptake inhibition (balanced) (1) · TrkB/BDNF'"`UNIQ--ref-00000084-QINU`"' '"`UNIQ--vote-00000085-QINU`"' (1)
uses:
None (1) · Depression, anxiety, neuropathic pain, fibromyalgia, chronic musculoskeletal pain (1) · '"`UNIQ--vote-000012CE-QINU`"', '"`UNIQ--vote-000012CF-QINU`"', '"`UNIQ--vote-000012D0-QINU`"' (1) · '"`UNIQ--vote-000012E5-QINU`"', '"`UNIQ--vote-000012E6-QINU`"', '"`UNIQ--vote-000012E7-QINU`"', '"`UNIQ--vote-000012E8-QINU`"' (1)
starting dose:
None (1) · 25 mg (1) · General supplementation 75-90 mg/d (RDA); scurvy treatment 100-1000 mg/d for several weeks; megadose claims unsupported (1) · Replacement: 15-30 mg (22.5-45 IU) daily; NASH: 800 IU daily; AREDS-2: 400 IU daily (in combination formula) (1)
preparations:
None (1) · 100, 200, 400 IU softgels and capsules; many proprietary OTC blends; combined formulations (AREDS-2) (1) · 100, 250, 500, 1000 mg tablets, chewables, gummies, effervescent; IV (specialty) (1) · 25 mg, 50 mg, 100 mg tablets; oral concentrate 20 mg/mL (1)
fda max:
None (1) · 200 mg/d (1) · UL 1000 mg (~1500 IU natural)/d in adults; routinely exceeded in older AREDS-1 trials (1) · UL 2000 mg/d in adults (1)
routes: (Click arrow to add another value)
onset:
Anxiolysis classically 3-4 weeks, continuing improvement to 8-12 weeks (1) · Days for symptom improvement in scurvy (1) · Days to weeks for tissue saturation (1) · Mood: 2–4 weeks. Pain: often within 1–2 weeks. (1)
duration:
Chronic daily dosing (1) · Hours (1) · Long (1) · Weeks (fat-soluble) (1)
halflife:
~10-20 days (steady-state body pool); single dose plasma ~2 hours (1) · ~12 hours (1) · ~26 h (sertraline; range 13-45 h, longer in females); ~62-104 h (N-desmethylsertraline, weakly active) (1) · ~3-4 days plasma; adipose tissue stores last months (1)
bioavailability:
Absolute bioavailability not precisely characterized; food modestly increases exposure (1) · High with fat-containing meal; reduced in malabsorption (1) · ~50% (highly variable) (1) · ~70-90% at typical doses; saturable at high doses (>500 mg) (1)
pregnancy:
Category C (1) · Category C'"`UNIQ--ref-0000008F-QINU`"' (1) · Safe at replacement doses; high-dose use generally avoided.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Safe at routine doses; routinely supplemented in pregnancy.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC in US (2) · Rx-only (1) · Rx-only in US (1)

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