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Medicines > classes : Antidepressant or [[:Category:Sulfonylureas|Sulfonylurea (second-generation)]] & routes: Oral

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generic:
Duloxetine (1) · Glipizide (1) · Sertraline (1)
brand:
Cymbalta, Drizalma Sprinkle, Irenka, Yentreve (1) · Glucotrol, Glucotrol XL (1) · Zoloft (1)
classes: (Click arrow to add another value)
mechanism:
Serotonin–norepinephrine reuptake inhibition (balanced) (1) · TrkB/BDNF'"`UNIQ--ref-00000084-QINU`"' '"`UNIQ--vote-00000085-QINU`"' (1) · '"`UNIQ--vote-000002D7-QINU`"' Hypoglycemia is the central risk, especially in elderly and renally impaired patients (glipizide has shorter half-life than glyburide, which is one reason it is preferred in older adults). CYP2C9 substrate; weight gain typical. (1)
uses:
None (1) · Depression, anxiety, neuropathic pain, fibromyalgia, chronic musculoskeletal pain (1) · '"`UNIQ--vote-000002D8-QINU`"' (1)
starting dose:
None (1) · 25 mg (1) · 5 mg PO once daily, 30 minutes before breakfast; XL: 5 mg with breakfast (1)
preparations:
None (1) · 25 mg, 50 mg, 100 mg tablets; oral concentrate 20 mg/mL (1) · 5 mg, 10 mg immediate-release tablets; 2.5 mg, 5 mg, 10 mg extended-release tablets (1)
fda max:
None (1) · 200 mg/d (1) · 40 mg/d (IR; doses >15 mg given as divided BID); 20 mg/d (XL) (1)
routes: (Click arrow to add another value)
onset:
Anxiolysis classically 3-4 weeks, continuing improvement to 8-12 weeks (1) · Mood: 2–4 weeks. Pain: often within 1–2 weeks. (1) · Within 30 minutes (IR) (1)
duration:
Chronic daily dosing (1) · Long (1) · ~12-24 hours (1)
halflife:
2-5 hours'"`UNIQ--ref-000002D9-QINU`"' (1) · ~12 hours (1) · ~26 h (sertraline; range 13-45 h, longer in females); ~62-104 h (N-desmethylsertraline, weakly active) (1)
bioavailability:
Absolute bioavailability not precisely characterized; food modestly increases exposure (1) · ~100% (oral; food delays absorption, hence pre-meal dosing for IR)'"`UNIQ--ref-000002DA-QINU`"' (1) · ~50% (highly variable) (1)
pregnancy:
Avoid; switch to insulin. Hypoglycemia in newborn reported.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1) · Category C (1) · Category C'"`UNIQ--ref-0000008F-QINU`"' (1)
legal:
Rx-only (1) · Rx-only in US (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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