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Medicines > classes : Antidepressant or [[:Category:Thiazide_diuretics|Thiazide diuretic]] & routes: Oral

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generic:
Duloxetine (1) · Hydrochlorothiazide (1) · Sertraline (1)
brand:
Cymbalta, Drizalma Sprinkle, Irenka, Yentreve (1) · Microzide; mostly prescribed generically (1) · Zoloft (1)
classes: (Click arrow to add another value)
mechanism:
Serotonin–norepinephrine reuptake inhibition (balanced) (1) · TrkB/BDNF'"`UNIQ--ref-00000084-QINU`"' '"`UNIQ--vote-00000085-QINU`"' (1) · '"`UNIQ--vote-00000138-QINU`"' Decreases urinary calcium (used in stone prevention); raises serum uric acid, glucose, and lipids modestly; non-anion-gap hypokalemic metabolic alkalosis is the characteristic electrolyte pattern'"`UNIQ--ref-00000139-QINU`"'. (1)
uses:
None (1) · Depression, anxiety, neuropathic pain, fibromyalgia, chronic musculoskeletal pain (1) · '"`UNIQ--vote-0000013A-QINU`"', '"`UNIQ--vote-0000013B-QINU`"', '"`UNIQ--vote-0000013C-QINU`"', '"`UNIQ--vote-0000013D-QINU`"' (1)
starting dose:
None (1) · 12.5-25 mg PO once daily (1) · 25 mg (1)
preparations:
None (1) · 12.5 mg capsules; 12.5, 25, 50 mg tablets (1) · 25 mg, 50 mg, 100 mg tablets; oral concentrate 20 mg/mL (1)
fda max:
None (1) · 200 mg/d (1) · 50 mg/d (hypertension); up to 200 mg/d (edema) (1)
routes: (Click arrow to add another value)
onset:
Anxiolysis classically 3-4 weeks, continuing improvement to 8-12 weeks (1) · Diuresis at 2 hours; antihypertensive effect within days, max at 3-4 weeks (1) · Mood: 2–4 weeks. Pain: often within 1–2 weeks. (1)
duration:
6-12 hours (1) · Chronic daily dosing (1) · Long (1)
halflife:
6-15 hours'"`UNIQ--ref-0000013E-QINU`"' (1) · ~12 hours (1) · ~26 h (sertraline; range 13-45 h, longer in females); ~62-104 h (N-desmethylsertraline, weakly active) (1)
bioavailability:
65-75% (oral)'"`UNIQ--ref-0000013F-QINU`"' (1) · Absolute bioavailability not precisely characterized; food modestly increases exposure (1) · ~50% (highly variable) (1)
pregnancy:
None (1) · Category C (1) · Category C'"`UNIQ--ref-0000008F-QINU`"' (1)
legal:
Rx-only (1) · Rx-only in US (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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