Drilldown: Medicines

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Medicines (732)

Medicines > classes

: Antidepressant

or Antiparkinsonian

or PDE5 Inhibitor

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Agomelatine (1) · Amantadine (1) · Amoxapine (1) · Apomorphine (1) · Avanafil (1) · Benztropine (1) · Biperiden (1) · Bromocriptine (1) · Cabergoline (1) · Carbidopa/levodopa (1) · Clomipramine (1) · Desipramine (1) · Duloxetine (1) · Entacapone (1) · Imipramine (1) · Isocarboxazid (1) · Levodopa (1) · Levomilnacipran (1) · Maprotiline (1) · Milnacipran (1) · Moclobemide (1) · Nefazodone (1) · Opicapone (1) · Phenelzine (1) · Protriptyline (1) · Rasagiline (1) · Reboxetine (1) · Rotigotine (1) · Safinamide (1) · Selegiline (1) · Sertraline (1) · Sildenafil (1) · Tadalafil (1) · Tianeptine (1) · Tolcapone (1) · Tranylcypromine (1) · Trihexyphenidyl (1) · Trimipramine (1) · Vardenafil (1)

None (2) · Akineton (1) · Anafranil (1) · Apokyn (1) · Artane (1) · Aurorix (1) · Azilect (1) · Cialis, Adcirca (1) · Cogentin (1) · Comtan (1) · Cymbalta, Drizalma Sprinkle, Irenka, Yentreve (1) · Dostinex (1) · Edronax (1) · Eldepryl (1) · Fetzima (1) · Levitra, Staxyn (1) · Ludiomil (1) · Marplan (1) · Nardil (1) · Neupro (1) · Norpramin (1) · Ongentys (1) · Parlodel (1) · Parnate (1) · Savella (1) · Serzone (1) · Sinemet (1) · Stablon (1) · Stendra (1) · Surmontil (1) · Symmetrel (1) · Tasmar (1) · Tofranil (1) · Valdoxan (1) · Viagra, Revatio (1) · Vivactil (1) · Xadago (1) · Zoloft (1)

Central and peripheral COMT inhibitor (1) · D1/D2/D3 receptor agonist (1) · D2 agonist; D1 partial agonist (1) · D2 receptor agonist (1) · Dopamine precursor (1) · Dopamine precursor + DOPA decarboxylase inhibitor (1) · Irreversible non-selective MAO inhibitor (3) · Irreversible selective MAO-B inhibitor (2) · MAO-B inhibitor; sodium channel blocker; glutamate release inhibitor (1) · Melatonin receptor agonist; 5-HT2C antagonist (1) · Mu-opioid agonist; modulates glutamate AMPA receptors (1) · Muscarinic receptor antagonist (1) · Muscarinic receptor antagonist; dopamine reuptake inhibitor (1) · NMDA antagonist; dopamine releasing agent (1) · Non-selective dopamine receptor agonist (1) · Once-daily COMT inhibitor (1) · Peripheral COMT inhibitor (1) · Potent serotonin reuptake inhibitor; also NRI (1) · Reversible inhibitor of MAO-A (1) · Selective inhibitor of PDE5 with a substantially longer half-life than other PDE5 inhibitors, allowing once-daily continuous dosing. (1) · Selective inhibitor of PDE5. Slightly higher PDE5/PDE6 selectivity vs sildenafil (less visual side effect) but more PDE1 cross-activity (occasional QT effects at high doses). (1) · Selective inhibitor of phosphodiesterase type 5 (PDE5), preventing cGMP breakdown in vascular smooth muscle. In the corpus cavernosum, potentiates the NO/cGMP cascade triggered by sexual stimulation. (1) · Selective inhibitor of phosphodiesterase type 5 (PDE5); increases cGMP in cavernous smooth muscle, producing erection in response to sexual stimulation. (1) · Selective M1 muscarinic antagonist (1) · Selective norepinephrine reuptake inhibitor (3) · Serotonin and norepinephrine reuptake inhibitor (3) · Serotonin reuptake inhibitor and 5-HT2A antagonist (1) · Serotonin–norepinephrine reuptake inhibition (balanced) (1) · Serotonin–norepinephrine reuptake inhibitor (2) · TrkB/BDNF'"`UNIQ--ref-00000084-QINU`"' '"`UNIQ--vote-00000085-QINU`"' (1) · Weak SRI; primarily H1/D2/alpha antagonist (1)

None (34) · Depression, anxiety, neuropathic pain, fibromyalgia, chronic musculoskeletal pain (1) · '"`UNIQ--vote-00000040-QINU`"' (1) · '"`UNIQ--vote-00000669-QINU`"' (1) · '"`UNIQ--vote-00000705-QINU`"', '"`UNIQ--vote-00000706-QINU`"' (1) · '"`UNIQ--vote-00000738-QINU`"', '"`UNIQ--vote-00000739-QINU`"', '"`UNIQ--vote-0000073A-QINU`"' (1)

None (34) · 10 mg PRN; 2.5–5 mg daily for continuous coverage / BPH (1) · 10 mg ~1 h before sexual activity (1) · 100 mg ~15 min before sexual activity (1) · 25 mg (1) · 50 mg ~1 h before sexual activity (ED); 20 mg TID (PAH) (1)

None (34) · 2.5, 5, 10, 20 mg tabs (1) · 2.5, 5, 10, 20 mg tabs (Levitra); 10 mg ODT (Staxyn) (1) · 25 mg, 50 mg, 100 mg tablets; oral concentrate 20 mg/mL (1) · 25, 50, 100 mg tabs (Viagra); 20 mg tabs and 10 mg/mL oral suspension (Revatio) (1) · 50, 100, 200 mg tabs (1)

None (34) · 100 mg/d (ED); 20 mg TID (PAH) (1) · 20 mg/d (1) · 20 mg/d (ED, PRN); 5 mg/d (daily / BPH); 40 mg/d (PAH) (1) · 200 mg/d (1) · 200 mg/d (100 mg/d if on CYP3A4 inhibitors) (1)

None (33) · IV (Revatio) (1) · Oral (6)

None (33) · 30 min (1) · 30–60 min (1) · Anxiolysis classically 3-4 weeks, continuing improvement to 8-12 weeks (1) · Mood: 2–4 weeks. Pain: often within 1–2 weeks. (1) · ~15 min (fastest of the PDE5 inhibitors) (1) · ~30 min (1)

None (33) · 4–5 h (1) · 4–6 h (1) · Chronic daily dosing (1) · Long (1) · Up to 36 h ("the weekend pill") (1) · ~4 h (1)

None (33) · 4–5 h (1) · ~12 hours (1) · ~17.5 h (1) · ~26 h (sertraline; range 13-45 h, longer in females); ~62-104 h (N-desmethylsertraline, weakly active) (1) · ~4 h (1) · ~5 h (1)

None (33) · Absolute bioavailability not precisely characterized; food modestly increases exposure (1) · Rapid absorption; absolute bioavailability not formally established (1) · Reasonable (not formally established as a percentage) (1) · ~15% (extensive hepatic first-pass) (1) · ~40% (1) · ~50% (highly variable) (1)

None (33) · Category B (3) · Category C (1) · Category C (not relevant; not used in women) (1) · Category C'"`UNIQ--ref-0000008F-QINU`"' (1)