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Medicines > classes : Antidepressant or Benzodiazepine or [[:Category:Tocolytics|Tocolytic (off-label)]]

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generic:
brand:
None (10) · Anafranil (1) · Aurorix (1) · Cymbalta, Drizalma Sprinkle, Irenka, Yentreve (1) · Dalmane (1) · Doral (1) · Edronax (1) · Fetzima (1) · Halcion (1) · Lexotan (1) · Librium (1) · Ludiomil (1) · Marplan (1) · Mogadon (1) · Nardil (1) · Norpramin (1) · Onfi (1) · Parnate (1) · Procardia, Procardia XL, Adalat CC, Afeditab CR (1) · ProSom (1) · Restoril (1) · Rohypnol (1) · Savella (1) · Serax (1) · Serzone (1) · Stablon (1) · Surmontil (1) · Tofranil (1) · Tranxene (1) · Valdoxan (1) · Versed (1) · Vivactil (1) · Xanax (1) · Zoloft (1)
classes: (Click arrow to add another value)
mechanism:
None (1) · Extremely potent GABAA positive allosteric modulator (1) · GABA-A positive allosteric modulator'"`UNIQ--ref-00000067-QINU`"' '"`UNIQ--vote-00000068-QINU`"' (1) · GABAA positive allosteric modulator (18) · GABAA positive allosteric modulator; low sedation (1) · GABAA positive allosteric modulator; prodrug of desmethyldiazepam (1) · GABAA positive allosteric modulator; very long half-life (1) · Irreversible non-selective MAO inhibitor (3) · Melatonin receptor agonist; 5-HT2C antagonist (1) · Mu-opioid agonist; modulates glutamate AMPA receptors (1) · Potent serotonin reuptake inhibitor; also NRI (1) · Reversible inhibitor of MAO-A (1) · Selective norepinephrine reuptake inhibitor (3) · Serotonin and norepinephrine reuptake inhibitor (3) · Serotonin reuptake inhibitor and 5-HT2A antagonist (1) · Serotonin–norepinephrine reuptake inhibition (balanced) (1) · Serotonin–norepinephrine reuptake inhibitor (2) · TrkB/BDNF'"`UNIQ--ref-00000084-QINU`"' '"`UNIQ--vote-00000085-QINU`"' (1) · Weak SRI; primarily H1/D2/alpha antagonist (1)
uses:
None (40) · Depression, anxiety, neuropathic pain, fibromyalgia, chronic musculoskeletal pain (1) · '"`UNIQ--vote-00000069-QINU`"', '"`UNIQ--vote-0000006A-QINU`"', '"`UNIQ--vote-0000006B-QINU`"' (1) · '"`UNIQ--vote-00000747-QINU`"', '"`UNIQ--vote-00000748-QINU`"', '"`UNIQ--vote-00000749-QINU`"', '"`UNIQ--vote-0000074A-QINU`"', '"`UNIQ--vote-0000074B-QINU`"', '"`UNIQ--vote-0000074C-QINU`"' (1)
starting dose:
None (40) · 0.25 mg (1) · 25 mg (1) · ER 30-60 mg PO once daily; immediate-release 10 mg PO TID (now rarely used for hypertension due to reflex tachycardia) (1)
preparations:
None (40) · 0.25 mg, 0.5 mg, 1 mg, 2 mg tablets (immediate-release and orally disintegrating); 0.5 mg, 1 mg, 2 mg, 3 mg extended-release tablets; 1 mg/mL oral concentrate (1) · 10, 20 mg IR capsules; 30, 60, 90 mg ER tablets (1) · 25 mg, 50 mg, 100 mg tablets; oral concentrate 20 mg/mL (1)
fda max:
None (40) · 10 mg/d (1) · 120 mg/d (ER); IR not for chronic hypertension (1) · 200 mg/d (1)
routes:
None (39) · MI reports) (1) · Oral (3) · Oral; sublingual IR is discouraged (uncontrolled BP drops (1)
onset:
None (39) · 30-60 min (immediate-release); 1-2 h (extended-release) (1) · Anxiolysis classically 3-4 weeks, continuing improvement to 8-12 weeks (1) · IR 20 minutes; ER ~6 hours (1) · Mood: 2–4 weeks. Pain: often within 1–2 weeks. (1)
duration:
None (39) · 6 h (immediate-release); ~11 h (extended-release) (1) · Chronic daily dosing (1) · IR 4-8 hours; ER 24 hours (1) · Long (1)
halflife:
None (39) · 11-13 h (immediate-release); 11-16 h (extended-release) (1) · 2-5 hours (IR); ER formulations extend functional duration via osmotic/matrix release'"`UNIQ--ref-0000074D-QINU`"' (1) · ~12 hours (1) · ~26 h (sertraline; range 13-45 h, longer in females); ~62-104 h (N-desmethylsertraline, weakly active) (1)
bioavailability:
None (39) · 80-90% oral (1) · Absolute bioavailability not precisely characterized; food modestly increases exposure (1) · ~50% (highly variable) (1) · ~50% IR (extensive first-pass via CYP3A4); ER products release-rate-limited'"`UNIQ--ref-0000074E-QINU`"' (1)
pregnancy:
None (39) · Category C (1) · Category C'"`UNIQ--ref-0000008F-QINU`"' (1) · Category D'"`UNIQ--ref-0000006C-QINU`"' (1) · Oral nifedipine is one of the preferred agents for severe hypertension in pregnancy and for tocolysis in preterm labor.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
None (39) · Rx-only (1) · Rx-only in US (1) · Schedule IV (US) (1) · [[USLegal:Prescription only|Rx-only]] in US (1)

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