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Drilldown: Medicines

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Medicines > classes : Antidepressant or Cardioselective (β1) & routes: Oral

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generic:
Bisoprolol (1) · Duloxetine (1) · Metoprolol (1) · Sertraline (1)
brand:
Cymbalta, Drizalma Sprinkle, Irenka, Yentreve (1) · Lopressor (tartrate), Toprol XL (succinate) (1) · Zebeta (1) · Zoloft (1)
classes: (Click arrow to add another value)
mechanism:
Cardioselective β1-adrenergic antagonist. Selectivity is dose-dependent and partially lost at higher doses. (1) · Highly β1-selective adrenergic antagonist. Greater selectivity than metoprolol or atenolol. (1) · Serotonin–norepinephrine reuptake inhibition (balanced) (1) · TrkB/BDNF'"`UNIQ--ref-00000084-QINU`"' '"`UNIQ--vote-00000085-QINU`"' (1)
uses:
None (1) · Depression, anxiety, neuropathic pain, fibromyalgia, chronic musculoskeletal pain (1) · '"`UNIQ--vote-000004F5-QINU`"', '"`UNIQ--vote-000004F6-QINU`"', '"`UNIQ--vote-000004F7-QINU`"', '"`UNIQ--vote-000004F8-QINU`"', '"`UNIQ--vote-000004F9-QINU`"' (1) · '"`UNIQ--vote-00000636-QINU`"', '"`UNIQ--vote-00000637-QINU`"', '"`UNIQ--vote-00000638-QINU`"' (1)
starting dose:
None (1) · 2.5–5 mg daily (HTN); 1.25 mg daily (HFrEF, slow titration) (1) · 25 mg (1) · 25–50 mg BID (tartrate); 25–100 mg daily (succinate); 12.5 mg daily in HFrEF (1)
preparations:
None (1) · 25 mg, 50 mg, 100 mg tablets; oral concentrate 20 mg/mL (1) · 5, 10 mg tabs (1) · Tartrate: 25, 50, 100 mg tabs; 1 mg/mL IV. Succinate ER: 25, 50, 100, 200 mg. (1)
fda max:
None (1) · 20 mg/d (1) · 200 mg/d (1) · 400 mg/d (1)
routes: (Click arrow to add another value)
onset:
1–2 h (1) · 1–2 h (PO); immediate (IV) (1) · Anxiolysis classically 3-4 weeks, continuing improvement to 8-12 weeks (1) · Mood: 2–4 weeks. Pain: often within 1–2 weeks. (1)
duration:
24 h (1) · 6–12 h (tartrate); 24 h (succinate) (1) · Chronic daily dosing (1) · Long (1)
halflife:
3–7 h (1) · 9–12 h (1) · ~12 hours (1) · ~26 h (sertraline; range 13-45 h, longer in females); ~62-104 h (N-desmethylsertraline, weakly active) (1)
bioavailability:
Absolute bioavailability not precisely characterized; food modestly increases exposure (1) · ~50% (1) · ~50% (highly variable) (1) · ~90% (low first-pass) (1)
pregnancy:
Category C (3) · Category C'"`UNIQ--ref-0000008F-QINU`"' (1)
legal:
Rx-only (1) · Rx-only in US (3)

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