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Medicines (732)

Medicines > classes

: Antidepressant

or Cardioselective (β1) + vasodilator

& routes: Oral

Use the filters below to narrow your results.

Duloxetine (1) · Nebivolol (1) · Sertraline (1)

Bystolic (1) · Cymbalta, Drizalma Sprinkle, Irenka, Yentreve (1) · Zoloft (1)

Serotonin–norepinephrine reuptake inhibition (balanced) (1) · The d-enantiomer is a highly β1-selective antagonist; the l-enantiomer triggers endothelial nitric-oxide–mediated vasodilation. Unique among beta blockers for this NO mechanism. (1) · TrkB/BDNF'"`UNIQ--ref-00000084-QINU`"' '"`UNIQ--vote-00000085-QINU`"' (1)

None (1) · Depression, anxiety, neuropathic pain, fibromyalgia, chronic musculoskeletal pain (1) · '"`UNIQ--vote-0000059D-QINU`"' (1)

None (1) · 25 mg (1) · 5 mg daily (1)

None (1) · 2.5, 5, 10, 20 mg tabs (1) · 25 mg, 50 mg, 100 mg tablets; oral concentrate 20 mg/mL (1)

None (1) · 200 mg/d (1) · 40 mg/d (1)

1–2 h (1) · Anxiolysis classically 3-4 weeks, continuing improvement to 8-12 weeks (1) · Mood: 2–4 weeks. Pain: often within 1–2 weeks. (1)

24 h (1) · Chronic daily dosing (1) · Long (1)

~10 h (CYP2D6 extensive metabolizers); up to 31 h (poor metabolizers) (1) · ~12 hours (1) · ~26 h (sertraline; range 13-45 h, longer in females); ~62-104 h (N-desmethylsertraline, weakly active) (1)

Absolute bioavailability not precisely characterized; food modestly increases exposure (1) · ~12% (extensive metabolizers); ~96% (poor metabolizers) (1) · ~50% (highly variable) (1)

Category C (2) · Category C'"`UNIQ--ref-0000008F-QINU`"' (1)

Rx-only (1) · Rx-only in US (2)

Showing below up to 3 results in range #1 to #3.

D

Duloxetine

N

Nebivolol

S

Sertraline

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