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Drilldown: Medicines

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Medicines > classes : Antidepressant or Rhapsodica & routes: Oral

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generic:
Artemisia absinthium (1) · Duloxetine (1) · Sertraline (1)
brand:
Cymbalta, Drizalma Sprinkle, Irenka, Yentreve (1) · Wormwood, absinthe, la Fée Verte, the Green Muse (1) · Zoloft (1)
classes: (Click arrow to add another value)
mechanism:
Active principle is thujone, a GABA-A antagonist (the opposite of most CNS depressants). Also present in cooking sage (''Salvia officinalis''), tansy, and ''Thuja'' cedars. (1) · Serotonin–norepinephrine reuptake inhibition (balanced) (1) · TrkB/BDNF'"`UNIQ--ref-00000084-QINU`"' '"`UNIQ--vote-00000085-QINU`"' (1)
uses:
None (1) · Depression, anxiety, neuropathic pain, fibromyalgia, chronic musculoskeletal pain (1) · '"`UNIQ--vote-00000008-QINU`"', '"`UNIQ--vote-00000009-QINU`"' (1)
starting dose:
None (1) · 25 mg (1) · A measured pour of absinthe diluted 5:1 with cold water over sugar (the louche ritual) (1)
preparations:
None (1) · 25 mg, 50 mg, 100 mg tablets; oral concentrate 20 mg/mL (1) · Dried leaves; absinthe liqueur (120–160 proof, with hyssop, lemon balm, fennel, anise, sometimes Acorus calamus) (1)
fda max:
None (2) · 200 mg/d (1)
routes: (Click arrow to add another value)
onset:
None (1) · Anxiolysis classically 3-4 weeks, continuing improvement to 8-12 weeks (1) · Mood: 2–4 weeks. Pain: often within 1–2 weeks. (1)
duration:
None (1) · Chronic daily dosing (1) · Long (1)
halflife:
None (1) · ~12 hours (1) · ~26 h (sertraline; range 13-45 h, longer in females); ~62-104 h (N-desmethylsertraline, weakly active) (1)
bioavailability:
None (1) · Absolute bioavailability not precisely characterized; food modestly increases exposure (1) · ~50% (highly variable) (1)
pregnancy:
None (1) · Category C (1) · Category C'"`UNIQ--ref-0000008F-QINU`"' (1)
legal:
Currently legal in most jurisdictions with thujone limits (1) · Rx-only (1) · Rx-only in US (1)

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