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Medicines > classes : Antiparkinsonian or Classic Psychedelic or [[:Category:Tryptamines|Tryptamine]]

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generic:
brand:
None (71) · Akineton (1) · Apokyn (1) · Artane (1) · Azilect (1) · Cogentin (1) · COMP360 (Compass Pathways, investigational synthesized clinical formulation) (1) · Comtan (1) · Delysid (historical, Sandoz, withdrawn 1965) (1) · Dostinex (1) · Eldepryl (1) · Neupro (1) · Ongentys (1) · Parlodel (1) · Sinemet (1) · Symmetrel (1) · Tasmar (1) · Xadago (1)
classes: (Click arrow to add another value)
mechanism:
5-HT2A agonist (26) · Potent 5-HT2A agonist (5) · LSD analogue; 5-HT2A agonist (4) · Prodrug of LSD; 5-HT2A agonist (4) · Contains LSA (2) · Contains mescaline (2) · Irreversible selective MAO-B inhibitor (2)
uses:
None (87) · (investigational) '"`UNIQ--vote-000000EF-QINU`"', '"`UNIQ--vote-000000F0-QINU`"', '"`UNIQ--vote-000000F1-QINU`"', '"`UNIQ--vote-000000F2-QINU`"', '"`UNIQ--vote-000000F3-QINU`"' (1)
starting dose:
None (87) · Modern clinical-trial standard: 25 mg synthesized psilocybin, single oral dose with psychological support (1)
preparations:
None (87) · Synthesized psilocybin capsules (COMP360 and other investigational formulations); dried whole [[Psilocybe|Psilocybe]] mushrooms (variable potency, no legal supply chain in most jurisdictions); psilocybin truffles (Psilocybe sclerotia, legal in the Netherlands) (1)
fda max:
None (87) · Not FDA-approved; clinical-trial protocols use up to 30 mg in adult investigational dosing (1)
routes:
None (86) · Oral (2)
onset:
None (86) · 20-45 min subjective onset; psilocin formation from psilocybin requires intestinal and hepatic alkaline phosphatase (1) · 30–60 minutes (1)
duration:
None (85) · 4-6 hours (1) · 8–12 hours (1) · About 20 minutes (1)
halflife:
None (85) · 3–5 hours (1) · 9–12 minutes (intravenous) (1) · Psilocin: ~2-3 h; psilocybin itself is a prodrug, dephosphorylated within minutes of absorption (1)
bioavailability:
None (86) · 70–90% (oral) (1) · Oral bioavailability of psilocin from administered psilocybin approximately 50% (1)
pregnancy:
None (86) · Not established (1) · Not studied in human pregnancy; no approved clinical use in any population (1)
legal:
None (86) · Schedule I (United States) (1) · [[USLegal:DEA Schedule I|Schedule I]] (United States) (1)

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