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Medicines > classes : Benzodiazepine or [[:Category:Analgesics|Non-opioid analgesic]] & routes: Oral

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generic:
Acetaminophen (paracetamol, APAP) (1) · Alprazolam (1)
brand:
Tylenol, Panadol (international), Ofirmev (IV); huge OTC presence (1) · Xanax (1)
classes: (Click arrow to add another value)
mechanism:
None (1) · GABA-A positive allosteric modulator'"`UNIQ--ref-00000067-QINU`"' '"`UNIQ--vote-00000068-QINU`"' (1)
uses:
'"`UNIQ--vote-0000001F-QINU`"', '"`UNIQ--vote-00000020-QINU`"', '"`UNIQ--vote-00000021-QINU`"' (1) · '"`UNIQ--vote-00000069-QINU`"', '"`UNIQ--vote-0000006A-QINU`"', '"`UNIQ--vote-0000006B-QINU`"' (1)
starting dose:
0.25 mg (1) · 325-1000 mg PO every 4-6 hours as needed; maximum 4 g/d in healthy adults, 3 g/d in regular users or hepatic risk; pediatric 10-15 mg/kg every 4-6 hours (1)
preparations:
0.25 mg, 0.5 mg, 1 mg, 2 mg tablets (immediate-release and orally disintegrating); 0.5 mg, 1 mg, 2 mg, 3 mg extended-release tablets; 1 mg/mL oral concentrate (1) · 325, 500, 650 mg tablets; 80, 160 mg chewables; 160 mg/5 mL pediatric liquid; 325 mg suppository; 1000 mg/100 mL IV (Ofirmev); fixed-dose combinations with opioids, decongestants, antihistamines (1)
fda max:
10 mg/d (1) · 4 g/d in healthy adults; 3 g/d conservative limit; 2 g/d in cirrhosis or chronic alcohol use (1)
routes: (Click arrow to add another value)
onset:
30-60 min (immediate-release); 1-2 h (extended-release) (1) · PO: 30-60 minutes; IV: minutes (1)
duration:
4-6 hours (1) · 6 h (immediate-release); ~11 h (extended-release) (1)
halflife:
1-3 hours (normal liver); markedly prolonged in overdose with glutathione depletion'"`UNIQ--ref-00000022-QINU`"' (1) · 11-13 h (immediate-release); 11-16 h (extended-release) (1)
bioavailability:
80-90% oral (1) · ~85-98% (oral)'"`UNIQ--ref-00000023-QINU`"' (1)
pregnancy:
Category D'"`UNIQ--ref-0000006C-QINU`"' (1) · Long the preferred analgesic-antipyretic in pregnancy; recent observational studies have raised speculative neurodevelopmental signals that remain under investigation.<sup class="pcp-cn" title="This claim needs a citation.">&#91;[[Pharmacopedia:Citation needed|citation&nbsp;needed]]&#93;</sup> (1)
legal:
OTC and [[USLegal:Prescription only|Rx-only]] (IV, combination products) in US (1) · Schedule IV (US) (1)

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