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Medicines > classes : Benzodiazepine or [[:Category:Antacids|Antacid]] & routes: Oral

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generic:
Alprazolam (1) · Sodium bicarbonate (1)
brand:
Neut, many generic; OTC oral: Alka-Seltzer (with aspirin/citric acid), baking soda (1) · Xanax (1)
classes: (Click arrow to add another value)
mechanism:
GABA-A positive allosteric modulator'"`UNIQ--ref-00000067-QINU`"' '"`UNIQ--vote-00000068-QINU`"' (1) · '"`UNIQ--vote-00000016-QINU`"' Bicarbonate is not benign: high-volume use produces hypernatremia, metabolic alkalosis, hypokalemia, and (in arrest) paradoxical intracellular acidosis'"`UNIQ--ref-00000017-QINU`"'. (1)
uses:
'"`UNIQ--vote-00000018-QINU`"', '"`UNIQ--vote-00000019-QINU`"', '"`UNIQ--vote-0000001A-QINU`"', '"`UNIQ--vote-0000001B-QINU`"', '"`UNIQ--vote-0000001C-QINU`"' (1) · '"`UNIQ--vote-00000069-QINU`"', '"`UNIQ--vote-0000006A-QINU`"', '"`UNIQ--vote-0000006B-QINU`"' (1)
starting dose:
0.25 mg (1) · IV: 1 mEq/kg bolus in arrest indication, then titrated to ABG and clinical status; PO: 325-2000 mg up to QID as antacid (1)
preparations:
0.25 mg, 0.5 mg, 1 mg, 2 mg tablets (immediate-release and orally disintegrating); 0.5 mg, 1 mg, 2 mg, 3 mg extended-release tablets; 1 mg/mL oral concentrate (1) · 4.2%, 7.5%, 8.4% IV (1 mEq/mL at 8.4%); 325, 650 mg oral tablets; bulk powder (1)
fda max:
10 mg/d (1) · No fixed maximum; titrated to pH and bicarbonate level; chronic high oral doses cause metabolic alkalosis and volume overload (1)
routes: (Click arrow to add another value)
onset:
30-60 min (immediate-release); 1-2 h (extended-release) (1) · Immediate (IV); within minutes (oral antacid) (1)
duration:
6 h (immediate-release); ~11 h (extended-release) (1) · IV: hours, dependent on ongoing acid load; oral antacid: ~30 minutes (1)
halflife:
11-13 h (immediate-release); 11-16 h (extended-release) (1) · Not applicable (electrolyte and buffer) (1)
bioavailability:
100% (IV); rapidly neutralized by gastric acid (oral) (1) · 80-90% oral (1)
pregnancy:
Category D'"`UNIQ--ref-0000006C-QINU`"' (1) · Routine antacid and acidosis correction acceptable (1)
legal:
Schedule IV (US) (1) · [[USLegal:Prescription only|Rx-only]] for IV formulations; OTC for oral (1)

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